Di Novi studied communications at Simmons College in Massachusetts, and received a degree in journalism. After working as a copy editor at the National Observer and staff writer for Canada AM, she became a reporter for Toronto's Citytv, but quit in 1980, taking a job as a unit publicist for Final Assignment. She became a principal in the Montreal-based production company Film Plan, acting in various production capacities on nine major studio releases, including Scanners (1981) and Videodrome (1983). In 1983, Film Plan relocated to Los Angeles and merged with Arnold Kopelson's Film Packages.[citation needed]
Di Novi joined New World Pictures as Executive Vice President of production. She later shifted into an overall deal as an independent producer, producing Heathers (1989) starring Winona Ryder. Di Novi then headed Tim Burton Productions and was responsible for producing several films. She set up her own production company, Di Novi Pictures, in 1993, at Columbia Pictures. She then entered into a producing deal with Warner Brothers Pictures.
For four years, Di Novi was executive producer of The District, a CBS primetime series created by Terry George. Di Novi made her directorial debut on the thriller Unforgettable (2017), for Warner Bros.[2]