Dystonin

DST
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3GJO
Identifiers
Aliases	DST, BPA, BPAG1, CATX-15, CATX15, D6S1101, DMH, DT, EBSB2, HSAN6, MACF2, dystonin, BP230, BP240, EBS3
External IDs	OMIM: 113810 HomoloGene: 134369 GeneCards: DST
Gene location (Human)
Chr.	Chromosome 6 (human)
End	56,954,830 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; Achilles tendon; ; internal globus pallidus; ; inferior olivary nucleus; ; external globus pallidus; ; subthalamic nucleus; ; inferior ganglion of vagus nerve; ; gastric mucosa; ; superior vestibular nucleus; ; trigeminal ganglion;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein homodimerization activity; microtubule plus-end binding; metal ion binding; integrin binding; protein C-terminus binding; protein binding; actin binding; microtubule binding; structural molecule activity; cytoskeletal protein binding;
Cellular component	cytoplasm; integral component of membrane; cell projection; nuclear envelope; endoplasmic reticulum membrane; membrane; focal adhesion; microtubule cytoskeleton; H zone; plasma membrane; hemidesmosome; microtubule plus-end; basement membrane; axon; cell junction; basal plasma membrane; cell cortex; Z disc; cell leading edge; endoplasmic reticulum; actin cytoskeleton; intermediate filament cytoskeleton; extracellular exosome; intermediate filament; cytoskeleton; microtubule; nucleus; cytosol; cytoplasmic vesicle; axon cytoplasm;
Biological process	hemidesmosome assembly; cell motility; cell adhesion; response to wounding; intermediate filament cytoskeleton organization; integrin-mediated signaling pathway; maintenance of cell polarity; microtubule cytoskeleton organization; retrograde axonal transport; cytoskeleton organization; cytoplasmic microtubule organization; wound healing;
	Sources:Amigo / QuickGO
Orthologs
	667
	n/a
	ENSG00000151914
	n/a
	Q03001
	n/a
NM_001144769; NM_001144770; NM_001144771; NM_001723; NM_015548;
	NM_020388; NM_183380; NM_001374722; NM_001374729; NM_001374730; NM_001374734; NM_001374736; NM_001386100
	n/a
NP_001138241; NP_001138242; NP_001714; NP_056363; NP_899236;
	NP_001361651; NP_001361658; NP_001361659; NP_001361663; NP_001361665
	n/a
	Wikidata
View/Edit Human

Bullous pemphigoid antigen 1, isoforms 1/2/3/4/5/8 is a protein that in humans is encoded by the DST gene.^[3]^[4]^[5]

Template:PBB Summary

Interactions

Dystonin has been shown to interact with Collagen, type XVII, alpha 1,^[6]^[7] DCTN1^[8] and Erbin.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151914 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Stanley JR, Tanaka T, Mueller S, Klaus-Kovtun V, Roop D (January 1989). "Isolation of complementary DNA for bullous pemphigoid antigen by use of patients' autoantibodies". J Clin Invest. 82 (6): 1864–70. doi:10.1172/JCI113803. PMC 442765. PMID 2461961.
^ Sawamura D, Nomura K, Sugita Y, Mattei MG, Chu ML, Knowlton R, Uitto J (March 1991). "Bullous pemphigoid antigen (BPAG1): cDNA cloning and mapping of the gene to the short arm of human chromosome 6". Genomics. 8 (4): 722–6. doi:10.1016/0888-7543(90)90261-R. PMID 2276744.
^ "Entrez Gene: DST dystonin".
^ Koster, January; Geerts Dirk; Favre Bertrand; Borradori Luca; Sonnenberg Arnoud (January 2003). "Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly". J. Cell. Sci. 116 (Pt 2). England: 387–99. doi:10.1242/jcs.00241. ISSN 0021-9533. PMID 12482924. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Hopkinson, S B; Jones J C (January 2000). "The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome". Mol. Biol. Cell. 11 (1). UNITED STATES: 277–86. doi:10.1091/mbc.11.1.277. ISSN 1059-1524. PMC 14774. PMID 10637308. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)
^ Liu, Jia-Jia; Ding Jianqing; Kowal Anthony S; Nardine Timothy; Allen Elizabeth; Delcroix Jean-Dominique; Wu Chengbiao; Mobley William; Fuchs Elaine; Yang Yanmin (October 2003). "BPAG1n4 is essential for retrograde axonal transport in sensory neurons". J. Cell Biol. 163 (2). United States: 223–9. doi:10.1083/jcb.200306075. ISSN 0021-9525. PMC 2173519. PMID 14581450. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Favre, B; Fontao L; Koster J; Shafaatian R; Jaunin F; Saurat J H; Sonnenberg A; Borradori L (August 2001). "The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression". J. Biol. Chem. 276 (35). United States: 32427–36. doi:10.1074/jbc.M011005200. ISSN 0021-9258. PMID 11375975. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

Dystonin

Interactions

See also

References

Further reading