Monosodium glutamate

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Monosodium glutamate
Chemical composition of monosodium glutamate
Monosodium glutamate spacefill.png
Monosodium glutamate crystals.jpg
IUPAC name
Sodium 2-aminopentanedioate
3D model (JSmol)
ECHA InfoCard 100.005.035
EC Number
  • 205-538-1
E number E621 (flavour enhancer)
Molar mass 169.111 g/mol (anhydrous), 187.127 g/mol (monohydrate)
Appearance White crystalline powder
Melting point 232 °C (450 °F; 505 K)
740 g/L
NFPA 704 (fire diamond)
Flammability code 0: Will not burn. E.g. waterHealth code 0: Exposure under fire conditions would offer no hazard beyond that of ordinary combustible material. E.g. sodium chlorideReactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no codeNFPA 704 four-colored diamond
Lethal dose or concentration (LD, LC):
15800 mg/kg (oral, rat)[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☑Y verify (what is ☑Y☒N ?)
Infobox references

Monosodium glutamate (MSG), also known as sodium glutamate, is the sodium salt of glutamic acid. MSG is found naturally in some foods including tomatoes and cheese.[2][3] MSG is used in cooking as a flavor enhancer with an umami taste that intensifies the meaty, savory flavor of food, as naturally occurring glutamate does in foods such as stews and meat soups.[4][5]

MSG was first prepared in 1908 by Japanese biochemist Kikunae Ikeda, who was trying to isolate and duplicate the savory taste of kombu, an edible seaweed used as a base for many Japanese soups. MSG balances, blends, and rounds the perception of other tastes.[6][7] MSG is commonly found in stock (bouillon) cubes, soups, ramen, gravy, stews, condiments, savoury snacks, etc.

The U.S. Food and Drug Administration has given MSG its generally recognized as safe (GRAS) designation.[8] It is a popular belief that MSG can cause headaches and other feelings of discomfort, known as "Chinese restaurant syndrome", but blinded studies show no such effects when MSG is combined with food in normal concentrations, and are inconclusive when MSG is added to broth in large concentrations.[8][9][10] The European Union classifies it as a food additive permitted in certain foods and subject to quantitative limits. MSG has the HS code 29224220 and the E number E621.[11]


Pure MSG is reported to not have a highly pleasant taste until it is combined with a savory aroma.[12] The basic sensory function of MSG is attributed to its ability to enhance savory taste-active compounds when added in the proper concentration.[6] The optimum concentration varies by food; in clear soup, the pleasure score rapidly falls with the addition of more than one gram of MSG per 100 mL.[13]

The sodium content (in mass percent) of MSG, 12%, is about one-third of that in sodium chloride (39%), due to the greater mass of the glutamate counterion.[14] Although other salts of glutamate have been used in low-salt soups, they are less palatable than MSG.[15] "MSG might even promote healthy eating, (food scientist Steve Witherly) hypothesizes, by not only making kale more delicious but also letting you get away with using less salt."[16]

MSG is commonly used and found in stock cubes (Bouillon cube), soups, ramen, gravy, stews, condiments, savoury snacks etc.

The ribonucleotide food additives disodium inosinate (E631) and disodium guanylate (E627), as well as conventional salt are usually used with monosodium glutamate-containing ingredients as they seem to have a synergistic effect. "Super salt" is a mixture of 9 parts salt, to one part MSG and 0.1 parts disodium inosinate and disodium guanylate.[17]


MSG is safe to eat.[2][18][19] A popular belief is that MSG can cause headaches and other feelings of discomfort but blinded tests have found no good evidence to support this.[9] International and national bodies governing food additives currently consider MSG safe for human consumption as a flavor enhancer.[20] Under normal conditions, humans can metabolize relatively large quantities of glutamate, which is naturally produced in the gut in the course of protein hydrolysis. The median lethal dose (LD50) is between 15 and 18 g/kg body weight in rats and mice, respectively, five times the LD50 of sodium chloride (3 g/kg in rats). The use of MSG as a food additive and the natural levels of glutamic acid in foods are not of toxic concern in humans.[20] Specifically MSG in the diet does not increase glutamate in the brain or affect brain function.[21]

A 1995 report from the Federation of American Societies for Experimental Biology (FASEB) for the United States Food and Drug Administration (FDA) concluded that MSG is safe when "eaten at customary levels" and, although a subgroup of otherwise-healthy individuals develop an MSG symptom complex when exposed to 3 g of MSG in the absence of food, MSG as a cause has not been established because the symptom reports are anecdotal.[22]

According to the report, no data supports the role of glutamate in chronic disease. High quality evidence has failed to demonstrate a relationship between the MSG symptom complex and actual MSG consumption. No association has been demonstrated, and the few responses were inconsistent. No symptoms were observed when MSG was administered with food.[23][24][25][26]

Adequately controlling for experimental bias includes a blinded, placebo-controlled experimental design and administration by capsule, because of the unique aftertaste of glutamates.[25] In a 1993 study, 71 fasting participants were given 5 g of MSG and then a standard breakfast. One reaction (to the placebo, in a self-identified MSG-sensitive individual) occurred.[23] A 2000 study tested the reaction of 130 subjects with a reported sensitivity to MSG. Multiple trials were performed, with subjects exhibiting at least two symptoms continuing. Two people out of the 130 responded to all four challenges. Because of the low prevalence, the researchers concluded that a response to MSG was not reproducible.[27]

Studies exploring MSG's role in obesity have yielded mixed results.[28][29]

Although several studies have investigated anecdotal links between MSG and asthma, current evidence does not support a causal association.[30] Since glutamates are important neurotransmitters in the human brain, playing a key role in learning and memory, ongoing neurological studies indicate a need for further research.[31]

Food Standards Australia New Zealand (FSANZ) MSG technical report concludes, "There is no convincing evidence that MSG is a significant factor in causing systemic reactions resulting in severe illness or mortality. The studies conducted to date on Chinese restaurant syndrome (CRS) have largely failed to demonstrate a causal association with MSG. Symptoms resembling those of CRS may be provoked in a clinical setting in small numbers of individuals by the administration of large doses of MSG without food. However, such effects are neither persistent nor serious and are likely to be attenuated when MSG is consumed with food. In terms of more serious adverse effects such as the triggering of bronchospasm in asthmatic individuals, the evidence does not indicate that MSG is a significant trigger factor."[32][33]

However, the FSANZ MSG report says that although no data is available on average MSG consumption in Australia and New Zealand, "data from the United Kingdom indicates an average intake of 590 mg/day, with extreme users (97.5th percentile consumers) consuming 2330 mg/day" (Rhodes et al. 1991). In a highly seasoned restaurant meal, intakes as high as 5000 mg or more may be possible (Yang et al. 1997). When very large doses of MSG (>5 g MSG in a bolus dose) are ingested, plasma glutamate concentration will significantly increase. However, the concentration typically returns to normal within two hours. In general, foods providing metabolizable carbohydrate significantly attenuate peak plasma glutamate levels at doses up to 150 mg/kg body weight. Two earlier studies – the 1987 Joint FAO/WHO Expert Committee on Food Additives (JECFA) and the 1995 Federation of American Societies for Experimental Biology (FASEB) – concluded, "there may be a small number of unstable asthmatics who respond to doses of 1.5–2.5 g of MSG in the absence of food". The FASEB evaluation concluded, "sufficient evidence exists to indicate some individuals may experience manifestations of CRS when exposed to a ≥3 g bolus dose of MSG in the absence of food".[32]


MSG has been produced by three methods: hydrolysis of vegetable proteins with hydrochloric acid to disrupt peptide bonds (1909–1962); direct chemical synthesis with acrylonitrile (1962–1973), and bacterial fermentation (the current method).[34] Wheat gluten was originally used for hydrolysis because it contains more than 30 g of glutamate and glutamine in 100 g of protein. As demand for MSG increased, chemical synthesis and fermentation were studied. The polyacrylic fiber industry began in Japan during the mid-1950s, and acrylonitrile was adopted as a base material to synthesize MSG.[35]

Currently (2016), most global MSG is produced by bacterial fermentation in a process similar to making vinegar or yogurt. Sodium is added later, for neutralization. During fermentation, Corynebacterium species, cultured with ammonia and carbohydrates from sugar beets, sugarcane, tapioca or molasses, excrete amino acids into a culture broth from which L-glutamate is isolated. The Kyowa Hakko Kogyo Company developed industrial fermentation to produce L-glutamate.[36]

The conversion yield and production rate (from sugars to glutamate) continues to improve in the industrial production of MSG, keeping up with demand.[34] The product, after filtration, concentration, acidification, and crystallization, is glutamate, sodium, and water.

Chemical properties[edit]

The compound is usually available as the monohydrate, a white, odorless, crystalline powder. The solid contains separate sodium cations Na+
and glutamate anions in zwitterionic form, OOC-CH(NH+
)2-COO.[37] In solution it dissociates into glutamate and sodium ions.

MSG is freely soluble in water, but it is not hygroscopic and is insoluble in common organic solvents (such as ether).[38] It is generally stable under food-processing conditions. MSG does not break down during cooking and, like other amino acids, will exhibit a Maillard reaction (browning) in the presence of sugars at very high temperatures.[39]


MSG has been used for more than 100 years to season food. Consumption and manufacture of high-salt and high-glutamate foods, which contain both sodium and glutamate, stretch back far longer, with evidence of cheese manufacture as early as 5,500 BCE.[40]

Glutamic acid was discovered and identified in 1866 by the German chemist Karl Heinrich Ritthausen, who treated wheat gluten (for which it was named) with sulfuric acid.[41] Kikunae Ikeda of Tokyo Imperial University isolated glutamic acid as a taste substance in 1908 from the seaweed Laminaria japonica (kombu) by aqueous extraction and crystallization, calling its taste umami.[42][43] Ikeda noticed that dashi, the Japanese broth of katsuobushi and kombu, had a unique taste not yet scientifically described (not sweet, salty, sour, or bitter).[42] To verify that ionized glutamate was responsible for umami, he studied the taste properties of glutamate salts: calcium, potassium, ammonium, and magnesium glutamate. All these salts elicited umami and a metallic taste due to the other minerals. Of them, sodium glutamate was the most soluble, most palatable, and easiest to crystallize.[citation needed] Ikeda called his product "monosodium glutamate", and submitted a patent to produce MSG;[44] the Suzuki brothers began commercial production of MSG in 1909 as Ajinomoto ("essence of taste").[34][39][45]

Society and culture[edit]


United States[edit]

MSG is one of several forms of glutamic acid found in foods, in large part because glutamic acid (an amino acid) is pervasive in nature. Glutamic acid and its salts may be present in a variety of other additives, including hydrolyzed vegetable protein, autolyzed yeast, hydrolyzed yeast, yeast extract, soy extracts, and protein isolate, which must be specifically labeled. Since 1998, MSG cannot be included in the term "spices and flavorings". However, the term "natural flavor" is used by the food industry for glutamic acid (chemically similar to MSG, lacking only the sodium ion). The Food and Drug Administration (FDA) does not require disclosure of components and amounts of "natural flavor."[46]

The FDA considers labels such as "no MSG" or "no added MSG" misleading if the food has ingredients which are sources of free glutamate, such as hydrolyzed protein. In 1993, it proposed adding "contains glutamate" to the common names of certain hydrolyzed proteins with substantial amounts of glutamate.[citation needed]

Australia and New Zealand[edit]

Standard 1.2.4 of the Australia and New Zealand Food Standards Code requires MSG to be labeled in packaged foods. The label must have the food-additive class name (e.g. "flavor enhancer"), followed by the name of the additive ("MSG") or its International Numbering System (INS) number, 621.[47]


The Punjab Food Authority banned Ajinomoto, commonly known as Chinese salt, which contains MSG, from being used in food products in the Punjab Province of Pakistan in January 2018.[48]


The following are alternative names for MSG:[1][49][50]

  • Chemical names and identifiers
    • Monosodium glutamate or sodium glutamate
    • Sodium 2-aminopentanedioate
    • Glutamic acid, monosodium salt, monohydrate
    • L-Glutamic acid, monosodium salt, monohydrate
    • L-Monosodium glutamate monohydrate
    • Monosodium L-glutamate monohydrate
    • MSG monohydrate
    • Sodium glutamate monohydrate
    • UNII-W81N5U6R6U
    • Flavour enhancer E621



A controversy surrounding the safety of MSG began on 4 April 1968, when Dr. Robert Ho Man Kwok wrote a letter to the New England Journal of Medicine, coining the term "Chinese restaurant syndrome".[56][57] In his letter, Kwok suggested several possible causes before he nominated MSG for his symptoms.[58][23] This letter was initially met with insider satirical responses, some using race as prop for humorous effect, within the medical community.[56] During the discursive uptake in media, the conversations were recontextualized as legitimate while the race-based motivations of the humor were not parsed and historical racial prejudice was perpetuated.[56]

In January 2018, Dr. Howard Steel claimed that the letter was actually a prank submission by him under a pseudonym.[57][59] However, it turned out that there was a Dr. Robert Ho Man Kwok who worked at the National Biomedical Research Foundation, both names Steel claimed to have invented.[59] Kwok's children, his colleague at the research foundation, and the son of his boss there confirmed that Dr. Robert Ho Man Kwok, who had died in 2014, wrote this letter.[59] After hearing about Kwok's family, Steel's daughter Anna came to believe this claim itself was one of the last pranks by her late father.[59]


MSG has been tied to racial stereotypes about East Asians,[60][61][62] with East Asian cuisine being targeted, while the widespread use of MSG in Western processed food hasn't been stigmatized.[63] The perpetuation of the negative image of MSG through the so-called Chinese restaurant syndrome has been attributed to xenophobic or racist biases.[64][65][66][67][68][69]

In 2020, Ajinomoto, along with other activists, launched the #RedefineCRS campaign to combat the myth that MSG is harmful to people's health, highlighting presumed xenophobic bias against East Asian cuisine and the scientific evidence that the myth is false.[70]

See also[edit]


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  67. ^ "Why Do People Freak Out About MSG in Chinese Food?". AJ+ (on YouTube). Al Jazeera Media Network. 14 August 2018.
  68. ^ Blythman, Joanna (21 May 2018). "Chinese restaurant syndrome: has MSG been unfairly demonised?". The Guardian. Although Chang doesn’t use MSG in his kitchens, he has defended its use, telling a high-level meeting of top chefs that Chinese restaurant syndrome is nothing more than a “cultural construct”. That is a polite way of saying that avoidance of MSG is an expression of western ignorance, or worse, racism, drawing on stereotypes of Asian countries as dangerous or dirty.
  69. ^ Geiling, Natasha (8 November 2013). "It's the Umami, Stupid. Why the Truth About MSG is So Easy to Swallow". Smithsonian. Everyone knows this connection, and probably associates MSG use in America most heavily with Chinese restaurants – thanks in large part to the absurdly racist name for MSG sensitivity “Chinese Restaurant Syndrome.”
  70. ^ Yeung, Jessie (19 January 2020). "MSG in Chinese food isn't unhealthy -- you're just racist, activists say". CNN.

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