Herle raised a Troop of Horse, at his own expense at the start of the Civil War and commanded them throughout. He was appointed High Sheriff of Cornwall in 1646 and in 1647 was appointed Vice-Admiral of the Coast for North Cornwall.
In 1659 Herle was elected MP for Fowey in the Third Protectorate Parliament. In April 1660 he was elected MP for Callington and Fowey in the Convention Parliament and chose to sit for Fowey. He was elected MP for Grampound in 1689.
He died in 1695 and was buried at Luxulyan, Cornwall. He married twice; firstly Mary, daughter and coheiress of Nicholas Trefusis of Lezant, with whom he had seven sons and three daughters and secondly Susanna, the widow of John Owen, a London fishmonger.
- Visitation of the County of Cornwall in the year 1630
- Willis, Browne (1750). Notitia Parliamentaria, Part II: A Series or Lists of the Representatives in the several Parliaments held from the Reformation 1541, to the Restoration 1660 ... London. pp. 229–239.
- : 'House of Lords Journal Volume 9: 11 December 1647', Journal of the House of Lords: volume 9: 1646 (1767-1830), pp. 570-573. Date accessed: 22 June 2011
- Leigh Rayment's Historical List of MPs – Constituencies beginning with "C" (part 1)[self-published source][better source needed]
- Leigh Rayment's Historical List of MPs – Constituencies beginning with "F" [self-published source][better source needed]
- "HERLE, Edward (c.1617-95), of Prideaux, Luxulyan, Cornw.". History of Parliament. Retrieved 2012-03-27.
|Parliament of England|
Parliament suspended since 1640
|Member of Parliament for Bossiney
With: Anthony Nicholl
Sir John Clotworthy
Not represented in restored Rump
|Member of Parliament for Fowey
With: John Barton