EggNOG (database)

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Description eorthologous groups covering
Research center European Molecular Biology Laboratory
Authors Sean Powell
Primary citation Powell & al. (2012)[1]
Release date 2011

The eggNOG database is a database of biological information hosted by the EMBL. It is based on the original idea of COGs (clusters of orthologous groups)[2][3] and expands that idea to non-supervised orthologous groups constructed from numerous organisms.[1] The database was created in 2007[4] and updated to version 4.5 in 2015.[5] eggNOG stands for evolutionary genealogy of genes: Non-supervised Orthologous Groups.


  1. ^ a b Powell, Sean; Szklarczyk Damian, Trachana Kalliopi, Roth Alexander, Kuhn Michael, Muller Jean, Arnold Roland, Rattei Thomas, Letunic Ivica, Doerks Tobias, Jensen Lars J, von Mering Christian, Bork Peer (Jan 2012). "eggNOG v3.0: orthologous groups covering 1133 organisms at 41 different taxonomic ranges". Nucleic Acids Research 40 (D1): D284–D289. doi:10.1093/nar/gkr1060. PMC 3245133. PMID 22096231.  Cite uses deprecated parameter |coauthors= (help)
  2. ^ Tatusov RL, Koonin EV, Lipman DJ (1997). "A genomic perspective on protein families". Science 278 (5338): 631–7. PMID 9381173. 
  3. ^ Tatusov RL, Galperin MY, Natale DA, Koonin EV (2000). "The COG database: a tool for genome-scale analysis of protein functions and evolution". Nucleic Acids Res. 28 (1): 33–6. PMC 102395. PMID 10592175. 
  4. ^ Jensen LJ, Julien P, Kuhn M, von Mering C, Muller J, Doerks T, Bork P (2008). "eggNOG: automated construction and annotation of orthologous groups of genes". Nucleic Acids Res. 36 (Database issue): D250–4. doi:10.1093/nar/gkm796. PMC 2238944. PMID 17942413. 
  5. ^ Huerta-Cepas J, Szklarczyk D, Forslund K, Cook H, Heller D, Walter MC, Rattei T, Mende DR, Sunagawa S, Kuhn M, Jensen LJ, von Mering C, Bork P (2016). "eggNOG 4.5: a hierarchical orthology framework with improved functional annotations for eukaryotic, prokaryotic and viral sequences". Nucleic Acids Res. 44 (D1): D286–93. doi:10.1093/nar/gkv1248. PMC 4702882. PMID 26582926. 

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