EggNOG (database)

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Description Database of orthologous proteins and functional annotations at multiple taxonomical levels.
Research center European Molecular Biology Laboratory
Authors Huerta-Cepas et al.
Primary citation Huerta-Cepas et al. (2015)[1]
Release date 2015

The eggNOG database is a database of biological information hosted by the EMBL. It is based on the original idea of COGs (clusters of orthologous groups)[2][3] and expands that idea to non-supervised orthologous groups constructed from numerous organisms.[4] The database was created in 2007[5] and updated to version 4.5 in 2015.[1] eggNOG stands for evolutionary genealogy of genes: Non-supervised Orthologous Groups.


  1. ^ a b Huerta-Cepas J, Szklarczyk D, Forslund K, Cook H, Heller D, Walter MC, Rattei T, Mende DR, Sunagawa S, Kuhn M, Jensen LJ, von Mering C, Bork P (2016). "eggNOG 4.5: a hierarchical orthology framework with improved functional annotations for eukaryotic, prokaryotic and viral sequences". Nucleic Acids Res. 44 (D1): D286–93. doi:10.1093/nar/gkv1248. PMC 4702882Freely accessible. PMID 26582926. 
  2. ^ Tatusov RL, Koonin EV, Lipman DJ (1997). "A genomic perspective on protein families". Science. 278 (5338): 631–7. doi:10.1126/science.278.5338.631. PMID 9381173. 
  3. ^ Tatusov RL, Galperin MY, Natale DA, Koonin EV (2000). "The COG database: a tool for genome-scale analysis of protein functions and evolution". Nucleic Acids Res. 28 (1): 33–6. doi:10.1093/nar/28.1.33. PMC 102395Freely accessible. PMID 10592175. 
  4. ^ Powell, Sean; Szklarczyk, Damian; Trachana, Kalliopi; Roth, Alexander; Kuhn, Michael; Muller, Jean; Arnold, Roland; Rattei, Thomas; Letunic, Ivica; Doerks, Tobias; Jensen, Lars J; von Mering, Christian; Bork Pee r (January 2012). "eggNOG v3.0: orthologous groups covering 1133 organisms at 41 different taxonomic ranges". Nucleic Acids Research. 40 (D1): D284–D289. doi:10.1093/nar/gkr1060. PMC 3245133Freely accessible. PMID 22096231. 
  5. ^ Jensen LJ, Julien P, Kuhn M, von Mering C, Muller J, Doerks T, Bork P (2008). "eggNOG: automated construction and annotation of orthologous groups of genes". Nucleic Acids Res. 36 (Database issue): D250–4. doi:10.1093/nar/gkm796. PMC 2238944Freely accessible. PMID 17942413. 

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