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Elafin

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PI3
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesPI3, ESI, SKALP, WAP3, WFDC14, cementoin, peptidase inhibitor 3
External IDsOMIM: 182257; HomoloGene: 122140; GeneCards: PI3; OMA:PI3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002638

n/a

RefSeq (protein)

NP_002629

n/a

Location (UCSC)Chr 20: 45.17 – 45.18 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Elafin, also known as peptidase inhibitor 3 or skin-derived antileukoprotease (SKALP), is a protein that in humans is encoded by the PI3 gene.[3][4][5]

Function

This gene encodes an elastase-specific protease inhibitor, which contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster.[5]

Clinical significance

Elafin has been found to have utility in serving as a biomarker for graft versus host disease of the skin.[6]

Elafin plays some role in gut inflammation. [7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124102Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Molhuizen HO, Zeeuwen PL, Olde Weghuis D, Geurts van Kessel A, Schalkwijk J (Feb 1994). "Assignment of the human gene encoding the epidermal serine proteinase inhibitor SKALP (PI3) to chromosome region 20q12→q13". Cytogenet Cell Genet. 66 (2): 129–31. doi:10.1159/000133683. PMID 8287685.
  4. ^ Clauss A, Lilja H, Lundwall A (Nov 2002). "A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein". Biochem J. 368 (Pt 1): 233–42. doi:10.1042/BJ20020869. PMC 1222987. PMID 12206714.
  5. ^ a b "Entrez Gene: PI3 peptidase inhibitor 3, skin-derived (SKALP)".
  6. ^ Paczesny S, Levine JE, Hogan J, Crawford J, Braun TM, Wang H, Faca V, Zhang Q, Pitteri S, Chin A, Choi SW, Kitko CL, Krijanovski OI, Reddy P, Mineishi S, Whitfield J, Jones S, Hanash SM, Ferrara JLM (February 2009). "[Elafin is a Biomarker of Graft Versus Host Disease of the Skin". Biology of Blood and Marrow Transplantation. 15 (2 Suppl 1): 13–14. doi:10.1016/j.bbmt.2008.12.039.
  7. ^ http://articles.latimes.com/2012/nov/01/news/la-heb-engineered-bacteria-crohns-and-colitis-20121031

Further reading

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