Endothelin 1
Template:PBB Endothelin 1 (ET-1), also known as preproendothelin-1 (PPET1), is a protein that in humans is encoded by the EDN1 gene. The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 is one of three isoforms of human endothelin.
Preproendothelin is precursor of the peptide ET-1. Endothelial cells convert preproendothelin to proendothelin and subsequently to mature endothelin, which the cells release.[1]
Endothelin-1 receptor antagonists (Bosentan) are used in the treatment of pulmonary hypertension. Inhibition of these receptors prevents pulmonary vasculature constriction and thus decreases pulmonary vascular resistance.
References
- ^ Boulpaep EL, Boron WF (2009). Medical physiology: a cellular and molecular approach. Saunders/Elsevier. ISBN 1-4160-3115-4.
Further reading
- Bruno CM, Neri S, Di Prima P, Sciacca C (2003). "Pathophysiology of endothelin and medical emergencies". Panminerva medica. 45 (2): 151–4. PMID 12855940.
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: CS1 maint: multiple names: authors list (link) - Doggrell SA (2006). "The endothelin system and its role in acute myocardial infarction". Expert Opin. Ther. Targets. 8 (3): 191–201. doi:10.1517/14728222.8.3.191. PMID 15161426.
- Beghetti M, Black SM, Fineman JR (2005). "Endothelin-1 in congenital heart disease". Pediatr. Res. 57 (5 Pt 2): 16R–20R. doi:10.1203/01.PDR.0000160447.83332.13. PMID 15817494.
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: CS1 maint: multiple names: authors list (link) - Cazaubon S, Deshayes F, Couraud PO, Nahmias C (2006). "[Endothelin-1, angiotensin II and cancer]". Med Sci (Paris). 22 (4): 416–22. doi:10.1051/medsci/2006224416. PMID 16597412.
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: CS1 maint: multiple names: authors list (link) - Ariza AC, Bobadilla NA, Halhali A (2007). "[Endothelin 1 and angiotensin II in preeeclampsia]". Rev. Invest. Clin. 59 (1): 48–56. PMID 17569300.
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: CS1 maint: multiple names: authors list (link)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.