Jump to content

Endothelin 1

From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by 90.221.85.74 (talk) at 21:34, 24 January 2016. The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Template:PBB Endothelin 1 (ET-1), also known as preproendothelin-1 (PPET1), is a protein that in humans is encoded by the EDN1 gene. The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 is one of three isoforms of human endothelin.

Preproendothelin is precursor of the peptide ET-1. Endothelial cells convert preproendothelin to proendothelin and subsequently to mature endothelin, which the cells release.[1]

Endothelin-1 receptor antagonists (Bosentan) are used in the treatment of pulmonary hypertension. Inhibition of these receptors prevents pulmonary vasculature constriction and thus decreases pulmonary vascular resistance.

References

  1. ^ Boulpaep EL, Boron WF (2009). Medical physiology: a cellular and molecular approach. Saunders/Elsevier. ISBN 1-4160-3115-4.

Further reading

  • Bruno CM, Neri S, Di Prima P, Sciacca C (2003). "Pathophysiology of endothelin and medical emergencies". Panminerva medica. 45 (2): 151–4. PMID 12855940.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Doggrell SA (2006). "The endothelin system and its role in acute myocardial infarction". Expert Opin. Ther. Targets. 8 (3): 191–201. doi:10.1517/14728222.8.3.191. PMID 15161426.
  • Beghetti M, Black SM, Fineman JR (2005). "Endothelin-1 in congenital heart disease". Pediatr. Res. 57 (5 Pt 2): 16R–20R. doi:10.1203/01.PDR.0000160447.83332.13. PMID 15817494.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Cazaubon S, Deshayes F, Couraud PO, Nahmias C (2006). "[Endothelin-1, angiotensin II and cancer]". Med Sci (Paris). 22 (4): 416–22. doi:10.1051/medsci/2006224416. PMID 16597412.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Ariza AC, Bobadilla NA, Halhali A (2007). "[Endothelin 1 and angiotensin II in preeeclampsia]". Rev. Invest. Clin. 59 (1): 48–56. PMID 17569300.{{cite journal}}: CS1 maint: multiple names: authors list (link)


Template:Peptidergics

Stub icon

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Endothelin_1&oldid=701483415"