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Enescu is a Romanian surname. Notable people with the surname include:
- Adrian Enescu (1948–2016), Romanian composer
- Andrei Enescu (born 1987), Romanian footballer
- George Enescu (1881–1955), Romanian classical violinist, pianist and composer
- Enescu Prize, Romanian prize in music composition founded by the Romanian composer George Enescu, awarded from 1913 to 1946, and afterwards by the National University of Music Bucharest.