Enterovirus cis-acting replication element

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Enterovirus cis-acting replication element
RF00048.jpg
Predicted secondary structure and sequence conservation of Entero_CRE
Identifiers
Symbol Entero_CRE
Alt. Symbols CRE
Rfam RF00048
Other data
RNA type Cis-reg
Domain(s) Viruses
SO 0000233

Enterovirus cis-acting replication element is a small RNA hairpin in the coding region of protein 2C as the site in PV1(M) RNA that is used as the primary template for the in vitro uridylylation.[1][2] The first step in the replication of the plus-stranded poliovirus RNA is the synthesis of a complementary minus strand. This process is initiated by the covalent attachment of uridine monophosphate (UMP) to the terminal protein VPg, yielding VPgpU and VPgpUpU.

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References[edit]

  1. ^ Paul, AV; Rieder E; Kim DW; van Boom JH; Wimmer E (2000). "Identification of an RNA hairpin in poliovirus RNA that serves as the primary template in the in vitro uridylylation of VPg". J Virol. 74 (22): 10359–10370. doi:10.1128/JVI.74.22.10359-10370.2000. PMC 110910Freely accessible. PMID 11044080. 
  2. ^ Goodfellow, I; Chaudhry Y; Richardson A; Meredith J; Almond JW; Barclay W; Evans DJ (2000). "Identification of a cis-acting replication element within the poliovirus coding region". J Virol. 74 (10): 4590–4600. doi:10.1128/JVI.74.10.4590-4600.2000. PMC 111979Freely accessible. PMID 10775595. 

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