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Epiphanius (//; "clearly manifested") may refer to:
- Saint Epiphanius of Salamis (c.310–20 to 403), bishop of Salamis, Cyprus, and author of the Panarion
- Annius Eucharius Epiphanius, praefectus urbi of the city of Rome, 412–414
- Saint Epiphanius of Pavia (438–496), Bishop of Pavia, Italy, 466–496
- Epiphanius Scholasticus (fl. c.510), translator of Greek works into Latin
- Epiphanius of Constantinople (died 535), Greek Ecumenical Patriarch of Constantinople, 520–535
- Epiphanius (Patriarch of Aquileia), first Patriarch of Aquileia to rule from Grado, Italy, 612–613
- Epiphanius the Monk (8th or 9th century), priest in the Kallistratos monastery, Constantinople
- Epiphanius the Wise (died 1420), Russian monk, hagiographer, and disciple of Saint Sergius of Radonezh
- Epiphanius Evesham (fl. 1570–c.1623), English sculptor
- Epiphanius Slavinetsky (died 1675), ecclesiastical expert of the Russian Orthodox Church
- Epiphanius Shanov (1849–1940), Bulgarian Uniate priest
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