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- Epiphanius of Pavia (439–496)
- Epiphanius of Salamis (ca 310–20 – 403), bishop of Salamis in Cyprus, author of the Panarion, or Medicine Chest against Heresies
- Epiphanius of Constantinople (520–535), Patriarch of Constantinople
- Epiphanius Scholasticus (6th century), assistant of Cassiodorus who compiled the Historiae Ecclesiasticae Tripartitae Epitome, ca. 510
- Epiphanius (Patriarch of Aquileia) (612-613)
- Epiphanius the Monk (8th century)
- Epiphanius Evesham (1570–1634), English sculptor
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