Epstein–Barr virus positive diffuse large B-cell lymphoma

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Epstein–Barr virus-positive DLBCL of the elderly is a type of large B-cell lymphoma, recognized in the WHO 2008 classification.[1][2]: 369–370 [3] It is usually CD20 positive, and has clonal immunoglobulin gene rearrangement.[2]: 380 

Biology

This type of lymphoma is not associated with immunodeficiency.[2]: 369  Although reported almost exclusively in Asians, it is not confined to that population.[2]: 369 [4] The disease usually has an extranodal presentation, with or without lymph node involvement.[2]: 369 

Morphologically, areas of necrosis are often seen[2]: 370 [3] as well as Reed–Sternberg-like cells.[2]: 370 [3] There are two subtypes: one with monotonous large cells, the other with numerous cell sizes as well as reactive cells, but different clinical behavior is not appreciated between these subtypes.[2]: 370  Morphological differential diagnosis is Hodgkin lymphoma.[2]: 370 

Median survival 2 years, 25% 5-year survival.[2]: 369 

See also

References

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  1. ^ Swerdlow, Steven H.; International Agency for Research on Cancer; World Health Organization (2008). WHO classification of tumours of haematopoietic and lymphoid tissues. World Health Organization classification of tumours. Vol. 2 (4th ed.). International Agency for Research on Cancer. ISBN 9789283224310.
  2. ^ a b c d e f g h i j Jaffe ES, Harris NL, Vardiman JW, Campo E, Arber, DA (2011). Hematopathology (1st ed.). Elsevier Saunders. ISBN 9780721600406.
  3. ^ a b c Adam P, Bonzheim I, Fend F, Quintanilla-Martínez L (2011). "Epstein-Barr virus-positive diffuse large B-cell lymphomas of the elderly". Adv Anat Pathol. 18 (5): 349–55. doi:10.1097/PAP.0b013e318229bf08. PMID 21841405.
  4. ^ Ok CY, Papathomas TG, Medeiros LJ, Young KH (2013). "EBV-positive diffuse large B-cell lymphoma of the elderly". Blood. 122 (3): 328–40. doi:10.1182/blood-2013-03-489708. PMC 3779382. PMID 23649469.
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