Epstein–Barr virus nuclear-antigen internal ribosomal entry site

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Epstein–Barr virus nuclear-antigen (EBNA) internal ribosome entry site (IRES)
RF00448.jpg
Predicted secondary structure and sequence conservation of IRES EBNA
Identifiers
Symbol IRES_EBNA
Rfam RF00448
Other data
RNA type Cis-reg; IRES
Domain(s) Viruses
GO 0043022
SO 0000243

The Epstein–Barr virus nuclear-antigen internal ribosome entry site (EBNA IRES) is an internal ribosome entry site (IRES) that is found in an exon in the 5' untranslated region of the Epstein–Barr virus nuclear antigen 1 (EBNA1) gene.[1] The EBNA IRES allows EBNA1 translation to occur under situations where initiation from the 5' cap structure and ribosome scanning is reduced. It is thought that the EBNA IRES is necessary for the regulation of latent-gene expression.[1]

The EBNA IRES is located in the U leader exon, which is a portion of the mRNA of the Epstein–Barr virus common to all four EBNA1 transcripts.[1]

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References[edit]

  1. ^ a b c Isaksson, A; Berggren M; Ricksten A (2003). "Epstein–Barr virus U leader exon contains an internal ribosome entry site". Oncogene. 22 (4): 572–581. doi:10.1038/sj.onc.1206149. PMID 12555070. 

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