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Erika Crouch

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Erika Crouch is a professor of pathology and the Carol B. and Jerome T. Loeb Professor of Medical Education at Washington University in St. Louis.

Early life and education

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Crouch received her B.S. from Washington State University in 1972.[1] Crouch earned her Ph.D. in 1978 and then her M.D. in 1979, both from the University of Washington. She was a postdoctoral fellow and then a resident in anatomic pathology at the University of Washington. She completed a fellowship in pulmonary pathology at the University of British Columbia as a Parker B. Francis Fellow.[2] In 1983 Crouch joined the Washington University in St. Louis faculty, and as of 2024 she is the Carol B. and Jerome T. Loeb Professor of Medical Education.[3]

Career and research

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Crouch is known for her research in collectins, a carbohydrate binding protein that is involved in the immune system.[4] She identified CP4, a novel secreted collagenous protein,[5] and went on to determine its molecular structure.[6] Working with John Heuser, she examined a surfactant protein, SP-D,[7][8] and researched the interactions between SP-D and influenza A virus.[9] She has also used structure-function analysis via crystallographic analysis and site-directed mutagenesis.[10]

Publications

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  • Crouch, E. (1990-10-01). "Pathobiology of pulmonary fibrosis". American Journal of Physiology. Lung Cellular and Molecular Physiology. 259 (4): L159–L184. doi:10.1152/ajplung.1990.259.4.L159. ISSN 1040-0605.
  • Kuan, S F; Rust, K; Crouch, E (1992-07-01). "Interactions of surfactant protein D with bacterial lipopolysaccharides. Surfactant protein D is an Escherichia coli-binding protein in bronchoalveolar lavage". Journal of Clinical Investigation. 90 (1): 97–106. doi:10.1172/JCI115861. ISSN 0021-9738. PMC 443067. PMID 1634623.
  • Crouch, Erika; Hartshorn, Kevan; Ofek, Itzhak (2000). "Collectins and pulmonary innate immunity". Immunological Reviews. 173 (1): 52–65. doi:10.1034/j.1600-065X.2000.917311.x. ISSN 0105-2896.
  • Crouch, Erika; Wright, Jo Rae (2001). "Surfactant Proteins A and D and Pulmonary Host Defense". Annual Review of Physiology. 63 (1): 521–554. doi:10.1146/annurev.physiol.63.1.521. ISSN 0066-4278.

References

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  1. ^ "Erika Crouch | Medical Scientist Training Program". Retrieved 2024-05-22.
  2. ^ "Erika Crouch and SP-D | Erika Crouch Lab". wupathlabs.wustl.edu. Retrieved 2023-02-28.
  3. ^ "Erika Crouch, MD, PhD | Pathology & Immunology | Washington University in St. Louis". pathology.wustl.edu. Retrieved 2023-02-28.
  4. ^ Crouch, Erika C. (1998-08-01). "Collectins and Pulmonary Host Defense". American Journal of Respiratory Cell and Molecular Biology. 19 (2): 177–201. doi:10.1165/ajrcmb.19.2.140. ISSN 1044-1549.
  5. ^ Persson, Anders; Rust, Kevin; Chang, Donald; Moxley, Michael; Longmore, William; Crouch, Edmound (1988-11-15). "CP4: a pneumocyte-derived collagenous surfactant-associated protein. Evidence for heterogeneity of collagenous surfactant proteins". Biochemistry. 27 (23): 8576–8584. doi:10.1021/bi00423a011. ISSN 0006-2960.
  6. ^ Crouch, E.; Persson, A.; Chang, D.; Heuser, J. (1994). "Molecular structure of pulmonary surfactant protein D (SP-D)". Journal of Biological Chemistry. 269 (25): 17311–17319. doi:10.1016/s0021-9258(17)32556-5. ISSN 0021-9258.
  7. ^ Crouch, Erika C. (1998-11-19). "Structure, biologic properties, and expression of surfactant protein D (SP-D)". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1408 (2): 278–289. doi:10.1016/S0925-4439(98)00073-8. ISSN 0925-4439.
  8. ^ Hanson, Phyllis I.; Stahl, Philip D. (2004). "From the neuromuscular junction to cellular architecture and beyond – commentary on 30 years of imaging by John E. Heuser". European Journal of Cell Biology. 83 (6): 229–242. doi:10.1078/0171-9335-00398. ISSN 0171-9335.
  9. ^ Hartshorn, K L; Crouch, E C; White, M R; Eggleton, P; Tauber, A I; Chang, D; Sastry, K (1994-07-01). "Evidence for a protective role of pulmonary surfactant protein D (SP-D) against influenza A viruses". Journal of Clinical Investigation. 94 (1): 311–319. doi:10.1172/JCI117323. ISSN 0021-9738. PMC 296311. PMID 8040272.
  10. ^ Seaton, Barbara A.; Crouch, Erika C.; McCormack, Francis X.; Head, James F.; Hartshorn, Kevan L.; Mendelsohn, Richard (2010). "Review: Structural determinants of pattern recognition by lung collectins". Innate Immunity. 16 (3): 143–150. doi:10.1177/1753425910368716. ISSN 1753-4259.
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