Palacio first studied theology before turning to music. He began his vocal studies in Milan, and after winning first prize in the "Voci Nuovi Rossiniane" competition organized by RAI in 1972, he made his debut on radio as Lindoro in L'italiana in Algeri.
He quickly sang all over Italy, including at La Scala in Milan and the San Carlo in Naples. He also appeared at the Royal Opera House in London, the Aix-en-Provence Festival, at the Liceo in Barcelona, etc.
One of the finest contemporary tenore di grazia, he possesses a small but well projected voice of considerable range and agility, used with fine musicianship, excelling in the Rossini-Donizetti-Bellini repertory, but also in Mozart and Cimarosa.
He has been lately active as a vocal coach and artist manager, notably of Juan Diego Florez.
- The Complete Dictionary of Opera & Operetta, James Anderson, (Wings Books, 1993). ISBN 0-517-09156-9