Escalante is a Spanish last name with meaning climber, or one who climbs. The Dictionary of American Family Names traces its origin to the Latin word scala referring to a terraced slope. Its origin is Sephardic (Jewish) from Cantabria, Spain.
- Amat Escalante, Mexican filmmaker
- Aníbal Escalante, economist and co-founder of the Communist Party of Cuba (PCC)
- Bernardino de Escalante, 16th-century Spanish writer, author of one of the first European books on China
- Enrique Escalante, Puerto Rican volleyball player
- Fabián Escalante, former chief of the Cuban secret service
- Francis García Escalante, Mexican transvestite who has become a famous actor
- Jaime Escalante (1930–2010), Bolivian former mathematics teacher
- Joe Escalante, the current bassist, and previous drummer for The Vandals
- Jorge Luis Volpi Escalante, Mexican writer
- Silvestre Vélez de Escalante, Spanish padre who in 1776 took an expedition through the Rocky Mountains, the eastern Great Basin, and the Colorado Plateau. As an early western explorer in southern Utah, there is a town, river, and national monument named after him.
- Wenceslao Escalante, a former Argentine Minister of Agriculture and Professor of Law
- Escalante, Negros Occidental, Philippines
- Escalante, Cantabria, Spain
- Escalante, Utah
- Escalante Desert
- Escalante River, Utah
- Escalante (crater), a crater on Mars
- Escalante Department, an administrative district in Argentina
- Grand Staircase-Escalante National Monument, Utah
- Rio Escalante, Nicaragua, a river in Nicaragua
- Escalante River (Venezuela)
- The Escalante, a Fred Harvey Hotel in Ash Fork, Arizona; closed in 1948
- 5095 Escalante, an asteroid
- Dictionary of American Family Names ©2013, Oxford University Press
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