Exosite
An exosite is a secondary binding site, remote from the active site, on an enzyme or other protein.[1]
This is similar to allosteric sites, but differs in the fact that, in order for an enzyme to be active, its exosite typically must be occupied.[2] Exosites have recently become a topic of increased interest in biomedical research as potential drug targets.[3][4]
References
- ^ IngentaConnect Manipulation of thrombin exosite I, by ligand-directed covalent m
- ^ Congress of the International Society on Thrombosis and Haemostasis Archived November 26, 2004, at the Wayback Machine
- ^ Muller, Jens. "An Exosite-Specific ssDNA Aptamer Inhibits the Anticoagulant Functions of Activated Protein C and Enhances Inhibition by Protein C Inhibitor". Cell.com. Retrieved 11 May 2013.
- ^ Serine Endopeptidases: Advances in Research and Application: 2011 Edition. ScholarlyAdditions. Retrieved 11 May 2013.
External links
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