FAD dependent oxidoreductase family
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|FAD dependent oxidoreductase|
crystal structure of d-amino acid oxidase in complex with two anthranylate molecules
In molecular biology, the FAD dependent oxidoreductase family of proteins is a family of FAD dependent oxidoreductases. Members of this family include Glycerol-3-phosphate dehydrogenase EC 126.96.36.199, Sarcosine oxidase beta subunit EC 188.8.131.52, D-amino-acid dehydrogenase EC 184.108.40.206, D-aspartate oxidase EC 220.127.116.11.
D-amino acid oxidase EC 18.104.22.168 (DAMOX or DAO) is an FAD flavoenzyme that catalyses the oxidation of neutral and basic D-amino acids into their corresponding keto acids. DAOs have been characterised and sequenced in fungi and vertebrates where they are known to be located in the peroxisomes.
D-aspartate oxidase EC 22.214.171.124 (DASOX)  is an enzyme, structurally related to DAO, which catalyses the same reaction but is active only toward dicarboxylic D-amino acids. In DAO, a conserved histidine has been shown  to be important for the enzyme's catalytic activity.
- D-amino-acid dehydrogenase
- D-amino acid oxidase
- D-aspartate oxidase
- Glycerol-3-phosphate dehydrogenase
- Sarcosine oxidase
- Negri A, Ceciliani F, Tedeschi G, Simonic T, Ronchi S (June 1992). "The primary structure of the flavoprotein D-aspartate oxidase from beef kidney". J. Biol. Chem. 267 (17): 11865–71. PMID 1601857.
- Miyano M, Fukui K, Watanabe F, Takahashi S, Tada M, Kanashiro M, Miyake Y (January 1991). "Studies on Phe-228 and Leu-307 recombinant mutants of porcine kidney D-amino acid oxidase: expression, purification, and characterization". J. Biochem. 109 (1): 171–7. PMID 1673125.