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FGF-1 internal ribosome entry site (IRES)

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FGF-1 internal ribosome entry site (IRES)
Predicted secondary structure and sequence conservation of IRES_FGF1
Identifiers
SymbolIRES_FGF1
RfamRF00387
Other data
RNA type Cis-reg; IRES
Domain(s)Eukaryota
GOGO:0043022
SOSO:0000243
PDB structuresPDBe

The FGF-1 internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of fibroblast growth factor-1 and allows cap-independent translation. It is thought that FGF-1 internal ribosome entry site (IRES) activity is strictly controlled and highly tissue specific.[1]

References

  1. ^ Martineau, Y; Le Bec C; Monbrun L; Allo V; Chiu IM; Danos O; Moine H; Prats H; Prats AC (2004). "Internal Ribosome Entry Site Structural Motifs Conserved among Mammalian Fibroblast Growth Factor 1 Alternatively Spliced mRNAs". Mol Cell Biol. 24 (17): 7622–7635. doi:10.1128/MCB.24.17.7622-7635.2004. PMC 507008. PMID 15314170.
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