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Fena may refer to:
- FENA, the Federal News Agency of the republic of Bosnia and Herzegovina
- Fractional sodium excretion (FENa), a medical parameter representing the fraction of sodium in urine relative to the fraction of sodium in circulation
- Fena Lake, the largest lake on the island of Guam
- Lori Fena (born 1961), American internet activist, entrepreneur, and author
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