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In theoretical physics, fine-tuning refers to circumstances when the parameters of a model must be adjusted very precisely in order to agree with observations. Theories requiring fine-tuning are regarded as problematic in the absence of a known mechanism to explain why the parameters happen to have precisely the needed values. The heuristic rule that parameters in a fundamental physical theory should not be too fine-tuned is called naturalness. Explanations often invoked to resolve fine-tuning problems include natural mechanisms by which the values of the parameters may be constrained to their observed values, and the anthropic principle.
The idea that Naturalness will explain fine tuning was brought into question by Nima Arkani-Hamed, a theoretical physicist, in his talk 'Why is there a Macroscopic Universe?', a lecture from the mini-series "Multiverse & Fine Tuning" from the "Philosophy of Cosmology" project, A University of Oxford and Cambridge Collaboration 2013. In it he describes how naturalness has usually provided a solution to problems in physics; and that it had usually done so earlier than expected. However, in addressing the problem of the cosmological constant, naturalness has failed to provide an explanation though it would have been expected to have done so a long time ago.
The necessity of fine-tuning leads to various problems that do not show that the theories are incorrect, in the sense of falsifying observations, but nevertheless suggest that a piece of the story is missing. For example, the cosmological constant problem (why is the cosmological constant so small?); the hierarchy problem; the strong CP problem, and others.
An example of a fine-tuning problem considered by the scientific community to have a plausible "natural" solution is the cosmological flatness problem, which is solved if inflationary theory is correct: inflation forces the universe to become very flat, answering the question of why the universe is today observed to be flat to such a high degree.