Flight Number 191 may refer to one of several flights which resulted in tragedy or near tragedy (as a result, the number has been withdrawn from use by several airlines):
- X-15 Flight 191 (1967), or X-15 Flight 3-65-97, experimental test plane, broke apart in flight, killing its test pilot
- Prinair Flight 191 (1972), crashed at Mercedita Airport in Ponce, Puerto Rico, killing five people
- American Airlines Flight 191 (1979), crashed shortly after takeoff from Chicago O'Hare Airport, killing 273
- Delta Air Lines Flight 191 (1985), crashed while on final approach to Dallas-Fort Worth International Airport, killing 137
- JetBlue Airways Flight 191 (2012), a flight from New York John F. Kennedy airport to Las Vegas, Nev. diverted to Amarillo, Tex. after the captain had an alleged panic attack, was locked out of the flight deck by the First Officer, and was restrained by passengers
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