Turrettini is especially known as a zealous opponent of the theology of the Academy of Saumur (embodied by Moise Amyraut and called Amyraldianism), as an earnest defender of the Calvinistic orthodoxy represented by the Synod of Dort, and as one of the authors of the Helvetic Consensus, which defended the formulation of predestination from the Synod of Dort and the verbal inspiration of the Bible.
He was the grandson of Francesco Turrettini, who left his native Lucca in 1574 and settled in Geneva in 1592. Francis was born to Bénédict Turrettini at Geneva on 17 October 1623 and died there on 28 September 1687. He studied theology at Geneva (1640–1644), Leiden (1644), Utrecht, Paris (1645–1646), Saumur (1646–1648), Montauban, and Nîmes. In Paris he also studied philosophy under Roman Catholic Pierre Gassendi. Returning to his native city, he was made pastor of the Italian church there from 1648 to 1687, of the French congregation from 1653-1687, and professor of theology at the University of Geneva in 1653. He is the father of Jean-Alphonse Turrettini, who would do much to dismantle the theology his father promoted.
His Institutio Theologiae Elencticae (3 parts, Geneva, 1679–1685) was the culmination of Reformed scholasticism. The Institutes uses the scholastic method to dispute a number of controversial issues. In it he defended the view that the Bible is God's verbally inspired word. He also argued for infralapsarianism and federal theology. The Institutes was widely used as a textbook, up to its use at Princeton Theological Seminary by the Princeton theologians only to be replaced by Charles Hodge's Systematic Theology in the late 19th century. Of his other disputations, his most important are De Satisfactione Christi disputationes (1666) and De necessaria secessione nostra ab Ecclesia Romana et impossibili cum ea syncretismo (published in 1687). He wrote the Helvetic Consensus, a Reformed confession written against Amyraldianism, with J. H. Heidegger in 1675.
Turrettini greatly influenced the Puritans, but until recently, he was a mostly forgotten Protestant scholastic from the annals of church history, though the English translation of his Institutes of Elenctic Theology is increasingly read by students of theology. John Gerstner called Turrettini "the most precise theologian in the Calvinistic tradition."
Along the lines of Reformed theology, Turrettini argues that after the fall human beings did not lose the faculty of will itself. "The inability to do good is strongly asserted, but the essence of freedom is not destroyed" (Institutio theologiae elencticae, 10.2.9). They still have liberty which is not repugnant to certain kinds of necessity. Turrettini distinguishes six kinds of necessity (Institutio, 10.2.4-9): physical necessity, necessity of coercion, necessity of dependence on God, rational necessity, moral necessity, and necessity of event. The first two among these six necessities are incompatible with freedom, whereas the latter four are not only compatible with freedom but perfect it. For Turrettini, freedom does not arise from an indifference of the will. No rational beings are indifferent to good and evil. The will of an individual human being is never indifferent in the sense of possessing an equilibrium, either before or after the fall. Turrettini defines freedom with the notion of rational spontaneity (Institutio, 10.2.10–11). 
Turrettini's doctrine of freedom appears to be similar to that of Scotus in that both of them endorse Aristotelian logic: the distinction between the necessity of the consequent (necessitas consequentis) and the necessity of the consequence (necessitas consequentiae); the distinction between in sensu composito and in sensu diviso. It is not Scotus's notion of synchronic contingency but Aristotle's modal logic which is incorporated into Turrettini's doctrine of freedom. Moreover, the Scotistic ideas about necessity and indifference differ greatly from those of Turrettini. Turrettini develops the discussion on necessity and relates it to his argument about human freedom of choice. His careful rejection of the notion of indifference in the doctrine of freedom creates a big gap between his doctrine and that of Scotus. Turrettini's teaching of contingency emphasizes the sovereign act of God in the process of conversion, whereas Scotus's contingency theory blurs it. Turrettini is not a Scotist, but a Reformed theologian standing in a more “generic Aristotelian tradition.”
- Institutes of Elenctic Theology. Translated by George Musgrave Giger, edited by James T. Dennison, Jr. (1992). ISBN 0-87552-451-6
- Justification an excerpt from Turretin's Institutes (2004). ISBN 0-87552-705-1
- The Atonement of Christ. Translated by James R. Willson (1978). ISBN 0-8010-8842-9
- Turrettini, François, in the Historical Dictionary of Switzerland.
- Chisholm, Hugh, ed. (1911). Encyclopædia Britannica. 28 (11th ed.). Cambridge University Press. p. 483. .
- Spencer 2000, p. 512.
- Spencer 2000, p. 513.
- Woo, B. Hoon (2016). "The Difference between Scotus and Turretin in Their Formulation of the Doctrine of Freedom". Westminster Theological Journal. 78: 263.
- Woo, B. Hoon (2016). "The Difference between Scotus and Turrettini in Their Formulation of the Doctrine of Freedom". Westminster Theological Journal. 78: 268–69.
- Spencer, Stephen R. (2000). "TURRETIN, FRANČOIS". In Carey, Patrick W.; Lienhard, Joseph T. Biographical Dictionary of Christian Theologians. Westport, CT: Greenwood Press – via Questia (subscription required). Retrieved 13 April 2013.
This article includes content derived from the public domain Schaff-Herzog Encyclopedia of Religious Knowledge, 1914.
- Works by François Turrettini at Post-Reformation Digital Library
- Brief Biography of Turretin - a brief biography of Francis Turretin based on an oral address given by his nephew, and translated into English
- Excerpts from Turretin's Institutes in English:
- Article on the Turretin family and the Institutes from the Princeton Review (July 1848)
- "Covenant Concepts in Francis Turretin's Institutes of Elenctic Theology" by C. Matthew McMahon
- "Turretin on Justification"[permanent dead link] an audio series by John Gerstner, long-time professor of church history.
- Woo, B. Hoon (2016). "The Difference between Scotus and Turretin in Their Formulation of the Doctrine of Freedom". Westminster Theological Journal. 78: 249–69.
| Chair of theology at the Genevan Academy
With: Théodore Tronchin (1653-1656)
Antoine Léger (1653-1654)
Philippe Mestrezat (1653-1687)
Louis Tronchin (de) (1661-1687)
Benedict Pictet (1686-1687)
Louis Tronchin (de)