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His interest in dance began when his grandmother took him to a meeting of her flamenco group when he was five years old. He began his dance training at Conservatorio Professional de Danza in Valencia and continued study at the Conservatorio de Danza in Madrid then joined Nacho Duato's Compania Nacional de Danza. In 2002, he joined the English National Ballet.
He played Bagoas opposite Colin Farrell in the 2004 Oliver Stone film Alexander. Their love scene was cut before distribution, as it was said to be too explicit. The dance scene shown in the movie has been detailed in Suzanne Gielgud's Dancing For Oliver documentary where Francisco is also interviewed.
Francisco has also completed filming in the 2006 films Nina's Heavenly Delights and Russell Mulcahy The Curse of King Tut's Tomb TV series. Francisco will appear in the The Magic Flute 2006 adaptation of Mozart's opera by Kenneth Branagh. His next movie project is with Layke Anderson in House of Boys by Jean-Claude Schlim.
In a July 23, 2013 interview with Out in the City magazine, Bosch confirmed that he is gay.
- "Lord of the Dance: Francisco Bosch". Out In the City Magazine. Sarah Garrett/Linda Riley. 23 July 2013. Retrieved 30 May 2015.