G protein-coupled receptor kinase 7
| G protein-coupled receptor kinase 7 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | GRK7 | ||||||
| Alt. symbols | GPRK7 | ||||||
| NCBI gene | 131890 | ||||||
| HGNC | 17031 | ||||||
| OMIM | 606987 | ||||||
| RefSeq | NM_139209 | ||||||
| UniProt | Q8WTQ7 | ||||||
| Other data | |||||||
| EC number | 2.7.11.14 | ||||||
| Locus | Chr. 3 q24 | ||||||
| |||||||
G protein-coupled receptor kinase 7 also known as GRK7 is an enzyme which in humans is encoded by the GRK7 gene.[1][2][3]
Function
This gene encodes a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation.[3]
References
- ^ Weiss ER, Ducceschi MH, Horner TJ, Li A, Craft CM, Osawa S (December 2001). "Species-specific differences in expression of G-protein-coupled receptor kinase (GRK) 7 and GRK1 in mammalian cone photoreceptor cells: implications for cone cell phototransduction". J. Neurosci. 21 (23): 9175–84. PMID 11717351.
- ^ Chen CK, Zhang K, Church-Kopish J, Huang W, Zhang H, Chen YJ, Frederick JM, Baehr W (December 2001). "Characterization of human GRK7 as a potential cone opsin kinase". Mol. Vis. 7: 305–13. PMID 11754336.
- ^ a b "Entrez Gene: GPRK7".
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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