Geissoschizine methyl ether

Geissoschizine methyl ether
Names
	IUPAC name Methyl (Z)-2-[(2S,3E,12bS)-3-ethylidene-2,4,6,7,12,12b-hexahydro-1H-indolo[2,3-a]quinolizin-2-yl]-3-methoxyprop-2-enoate
Identifiers
3D model (JSmol)	Interactive image;
PubChem CID	6443046;
CompTox Dashboard (EPA)	DTXSID101045604 ;
	SMILES C/C=C\1/CN2CCC3=C([C@@H]2C[C@@H]1/C(=C/OC)/C(=O)OC)NC4=CC=CC=C34;
Properties
Chemical formula	C22H26N2O3
Molar mass	366.461 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Geissoschizine methyl ether is an alkalod contained in the kampo medicine Yokukansan. Geissoschizine methyl ether has an antagonistic effect on 5-HT₇ receptors.^[1]

References

^ Ueki, T; Nishi, A; Imamura, S; Kanno, H; Mizoguchi, K; Sekiguchi, K; Ikarashi, Y; Kase, Y (2013). "Effects of geissoschizine methyl ether, an indole alkaloid in Uncaria hook, a constituent of yokukansan, on human recombinant serotonin(7) receptor". Cellular and molecular neurobiology. 33 (1): 129–35. doi:10.1007/s10571-012-9878-3. PMID 22968712.

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[1] Ueki, T; Nishi, A; Imamura, S; Kanno, H; Mizoguchi, K; Sekiguchi, K; Ikarashi, Y; Kase, Y (2013). "Effects of geissoschizine methyl ether, an indole alkaloid in Uncaria hook, a constituent of yokukansan, on human recombinant serotonin(7) receptor". Cellular and molecular neurobiology. 33 (1): 129–35. doi:10.1007/s10571-012-9878-3. PMID 22968712.

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