George Downame was born at Chester, where his father William Downham was the bishop. He studied at Cambridge and was elected fellow of Christ's College in 1585. Later he was appointed professor of logic and granted the D.D. degree. In 1616 he became bishop of Derry. He died after a long preaching ministry. He married in 1617 Jael de Peigne, widow of Sir Henry Killigrew; she died c.1632.
His A Treatise of Justification, published in 1639, was his outstanding work. Downame's other writings included:
- A Treatise Concerning Anti-christ (1603)
- An Abstract of the Duties Commanded in the Law of God (1635)
- The Christian’s Freedom (1635)
- A Godly and Learned Treatise of Prayer (1640).
- Dictionary of National Biography. London: Smith, Elder & Co. 1885–1900. .
- "Downham, George (DWNN581G)". A Cambridge Alumni Database. University of Cambridge.
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