George Sai Wah Tsao
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George Sai Wah Tsao (Chinese: 曹世華) was a professor of the School of Biomedical Sciences of the University of Hong Kong and the Director of the Faculty Core Facility of the Faculty of Medicine, the University of Hong Kong.[1] Tsao researches the relationship between Epstein-Barr virus and nasopharyngeal carcinoma. He also created the first immortal human ovarian surface epithelial cell line.[2]
Education
[edit]Tsao graduated from the Chinese University of Hong Kong with a BSc degree, and received his PhD training at the University of London, Royal Marsden Hospital.[3]
Career
[edit]Tsao became a faculty member of the Chinese University of Hong Kong after receiving postgraduate training. However, he went to the Harvard Medical School to receive further postdoctoral training in 1987. Later on, he was appointed the Laboratory Director of the Gynecological Oncology Division, Brigham and Women's Hospital and assistant professor in Obstetrics and Gynecology, Harvard Medical School.[3] He joined the University of Hong Kong in 1993, and is currently a faculty member of the Department of Anatomy and the deputy director of the Center for Cancer Research, the University of Hong Kong Li Ka Shing Faculty of Medicine.[4]
Tsao passed away in December 2022.
Research
[edit]Tsao's main research interest is nasopharyngeal carcinoma and Epstein-Barr virus, involving cell immortalization and malignant transformation. Emphasis is put on the relationship between latent infection of nasopharyngeal epithelial cells by Epstein-Barr virus and nasopharyngeal carcinoma.[5][6][7]
References
[edit]- ^ "Professor TSAO, George Sai Wah". Archived from the original on 2017-06-17. Retrieved 2017-06-27.
- ^ Characterization of human ovarian surface epithelial cells immortalized by human papilloma viral oncogenes (HPV-E6E7 ORFs)
- ^ a b "George Sai Wah Tsao, The University of Hong Kong - Professor, Department of Anatomy" (PDF). Archived from the original (PDF) on 2017-08-16.
- ^ "Center for Cancer Research, the University of Hong Kong Li Ka Shing Faculty of Medicine".
- ^ Zhang J, Jia L, Lin W, Yip YL, Lo KW, Lau VM, Zhu D, Tsang CM, Zhou Y, Deng W, Lung HL, Lung ML, Cheung LM, Tsao SW. Epstein-Barr Virus encoded Latent Membrane Protein-1 upregulates glucose transporter-1 transcription via the mTORC1/NF-κB signaling pathways. J Virol. 2017. In press.
- ^ Tsang CM, Yip YL, Lo KW, Deng W, To KF, Hau PM, Lau VM, Takada K, Lui VW, Lung ML, Chen H, Zeng M, Middeldorp JM, Cheung AL, Tsao SW (2012). Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells. Proc.Natl.Acad.Sci.U.S.A 109, E3473-E3482.
- ^ Li HM, Zhuang ZH, Wang Q, Pang JC, Wang XH, Wong HL, Feng HC, Jin DY, Ling MT, Wong YC, Eliopoulos AG, Young LS, Huang DP, Tsao SW. Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells. Oncogene, 23(25):4488-94, 2004.