Ghrelin O-acyltransferase

MBOAT4
Identifiers
Aliases	MBOAT4, GOAT, OACT4, FKSG89, membrane bound O-acyltransferase domain containing 4
External IDs	OMIM: 611940 MGI: 2685017 HomoloGene: 19272 GeneCards: MBOAT4
Gene location (Human) Chr. Chromosome 8 (human) Band 8p12 Start 30,131,671 bp End 30,144,665 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 A4 Start 34,582,184 bp End 34,592,336 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans gallbladder blood right uterine tube body of pancreas left adrenal gland lymph node duodenum monocyte stromal cell of endometrium Top expressed in morula facial motor nucleus piriform cortex subiculum medial geniculate nucleus hair follicle Paneth cell paraventricular nucleus of hypothalamus primary motor cortex pontine nuclei More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity serine O-acyltransferase activity acyltransferase activity O-acyltransferase activity Cellular component integral component of membrane integral component of endoplasmic reticulum membrane endoplasmic reticulum membrane endoplasmic reticulum membrane Biological process peptidyl-serine octanoylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 619373 234155 Ensembl ENSG00000177669 ENSMUSG00000071113 UniProt Q96T53 P0C7A3 RefSeq (mRNA) NM_001100916 NM_001126314 RefSeq (protein) NP_001094386 NP_001119786 Location (UCSC) Chr 8: 30.13 – 30.14 Mb Chr 8: 34.58 – 34.59 Mb PubMed search
Wikidata
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Ghrelin O-acyltransferase also known as membrane bound O-acyltransferase domain containing 4 is an enzyme that in humans is encoded by the MBOAT4 gene. It is homologous to other membrane-bound O-acyltransferases.

Further Reading

• Gómez, R; Lago, F; Gómez-Reino, J. J.; Dieguez, C; Gualillo, O (2009). "Expression and modulation of ghrelin O-acyltransferase in cultured chondrocytes". Arthritis & Rheumatism. 60 (6): 1704–9. doi:10.1002/art.24522. PMID 19479831.
• Gutierrez, J. A.; Solenberg, P. J.; Perkins, D. R.; Willency, J. A.; Knierman, M. D.; Jin, Z; Witcher, D. R.; Luo, S; Onyia, J. E.; Hale, J. E. (2008). "Ghrelin octanoylation mediated by an orphan lipid transferase". Proceedings of the National Academy of Sciences. 105 (17): 6320–5. doi:10.1073/pnas.0800708105. PMC 2359796. PMID 18443287.
• Rodríguez, A; Gómez-Ambrosi, J; Catalán, V; Rotellar, F; Valentí, V; Silva, C; Mugueta, C; Pulido, M. R.; Vázquez, R; Salvador, J; Malagón, M. M.; Colina, I; Frühbeck, G (2012). "The ghrelin O-acyltransferase-ghrelin system reduces TNF-α-induced apoptosis and autophagy in human visceral adipocytes". Diabetologia. 55 (11): 3038–50. doi:10.1007/s00125-012-2671-5. PMID 22869322.
• Takahashi, T; Ida, T; Sato, T; Nakashima, Y; Nakamura, Y; Tsuji, A; Kojima, M (2009). "Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid". Journal of Biochemistry. 146 (5): 675–82. doi:10.1093/jb/mvp112. PMID 19628676.
• Lim, C. T.; Kola, B; Grossman, A; Korbonits, M (2011). "The expression of ghrelin O-acyltransferase (GOAT) in human tissues". Endocrine journal. 58 (8): 707–10. doi:10.1507/endocrj.k11e-117. PMID 21646729.
• Liu, B; Garcia, E. A.; Korbonits, M (2011). "Genetic studies on the ghrelin, growth hormone secretagogue receptor (GHSR) and ghrelin O-acyl transferase (GOAT) genes". Peptides. 32 (11): 2191–207. doi:10.1016/j.peptides.2011.09.006. PMID 21930173.
• Heppner, K. M.; Tong, J; Kirchner, H; Nass, R; Tschöp, M. H. (2011). "The ghrelin O-acyltransferase-ghrelin system: A novel regulator of glucose metabolism". Current Opinion in Endocrinology, Diabetes and Obesity. 18 (1): 50–5. doi:10.1097/MED.0b013e328341e1d3. PMID 21150588.
• Müller, T. D.; Tschöp, M. H.; Jarick, I; Ehrlich, S; Scherag, S; Herpertz-Dahlmann, B; Zipfel, S; Herzog, W; De Zwaan, M; Burghardt, R; Fleischhaker, C; Klampfl, K; Wewetzer, C; Herpertz, S; Zeeck, A; Tagay, S; Burgmer, M; Pfluger, P. T.; Scherag, A; Hebebrand, J; Hinney, A (2011). "Genetic variation of the ghrelin activator gene ghrelin O-acyltransferase (GOAT) is associated with anorexia nervosa". Journal of Psychiatric Research. 45 (5): 706–11. doi:10.1016/j.jpsychires.2010.10.001. PMID 21035823.