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Giant-killing or giant killer may refer to:
- Upset (competition), in a contest, especially in sport, when an underdog beats the strong favourite
- Killing a literal giant, such as:
- Giant Killing, a manga series with a 26 episode anime adaptation
- Giantkiller, a DC Comics comic book series
- Giant Killer (call sign), a call sign in military aviation in the United States
- "Giant Killer" (story), a 1945 sci-fi story by A. Bertram Chandler
| disambiguation page lists articles associated with the title Giant-killing.
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