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Gluma is a brand-name desensitizer, used in dentistry to treat sensitivity, product created by manufacturer Heraeus Kulzer, a German company.


Its formula of 5% glutaraldehyde and 35% HEMA (hydroxyethyl methacrylate) in water[1] is used to help control both hypersensitive dentin and reduce the incidence of post-operative sensitivity in restorative dentistry procedures. It’s also useful as a cavity disinfectant, a rewetting agent and an adhesion promoter (when combined with most dentin bonding systems).

Research indicates that when used as a desensitizer under bonded restorative material, Gluma has no significant influence on bond strength, unlike some other liners, which contribute to a decrease in bond strength.[2] In one study, potassium nitrate was more effective at reducing sensitivity.[3]

Method of action[edit]

The glutaraldehyde in Gluma works by occluding (blocking) the microscopic tubules that compose dentin, thereby preventing the flow of fluid and decreasing sensitivity.[4]

Gluteraldehyde induces coagulation of proteins in dentinal tubules, which reacts with the serum albumin in the dentinal fluid to cause its precipitation. HEMA forms deep resinous tags and then occludes the dentinal tubules.[5]


  1. ^ Heraeus-Kulzer: GLUMA
  2. ^ Kobler, A; Schaller, HG; Gernhardt, CR: Effects of the desensitizing agents Gluma and Hyposen on the tensile bond strength of dentin adhesives. Am J Dent 2008 Dec;21(6):388-92.
  3. ^ Jalalian, E; Meraji, N; Mirzaei, M: A Comparison of the Efficacy of Potassium Nitrate and Gluma Desensitizer in the Reduction of Hypersensitivity in Teeth with Full Crown Restorations. J Contemp Dent Pract 2009 January; (10)1:066-073.
  4. ^ Schüpbach, P; Lutz, F; Finger, WJ: Closing of dentinal tubules by Gluma desensitizer. European J Oral Sci 1997;105(5 Pt 1):414-2
  5. ^ Sanjay Miglani, Vivek Aggarwal, and Bhoomika Ahuja: Dentin hypersensitivity: Recent trends in management. J Conserv Dent 2010 Oct-Dec;13(4): 218–224

External links[edit]