Gruffudd Fychan (antiquarian spelling: Gruffydd Fychan) could refer to:
- Gruffudd Fychan I, Prince of Powys Fadog (reigned 1277-84)
- Gruffudd Fychan II (c. 1330-1369), Lord of Glyndyfrdwy and Cynllaith and father of Owain Glyndŵr, Prince of Wales
- Gruffudd Fychan ap Gruffudd ab Ednyfed (14th century), a Welsh-language poet
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