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Guff may refer to:
- Commodore Guff, a character in the game Magic: The Gathering
- Surname of various characters in the comic strip The Teenie Weenies
- nickname of a statue in Herald Square, New York City
- Guff, Punjab, a place in Pakistan
- GUFF (production company/ art collective)
|This disambiguation page lists articles associated with the title Guff.
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