Guoping Feng
Guoping Feng | |
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| Born | |
| Alma mater |
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| Known for | Animal models of psychiatric disease |
| Awards | |
| Scientific career | |
| Fields | Neurobiology |
| Institutions | |
| Doctoral advisor | Linda Hall |
Guoping Feng is the Poitras Professor of Neuroscience at the McGovern Institute for Brain Research in the Department of Brain and Cognitive Sciences at MIT[3][4] and member of the Stanley Center for Psychiatric Research at Broad Institute most notable for studying the synaptic mechanisms underlying psychiatric disease.[5] In addition to developing many genetic-based imaging tools for the study of molecular mechanisms in the brain,[6] he has generated and characterized rodent models of obsessive-compulsive disorder,[7][8] autism spectrum disorders,[9] and schizophrenia.[10] Feng has also shown that some autism-like behaviors can be corrected in adult mice by manipulating the expression of the Shank3 gene.[11]
Selected publications
- Mei Y, Monteiro P, Zhou Y, Kim J, Gao X, Fu Z, Feng G. (2016) Adult restoration of Shank3 expression rescues selective autistic-like phenotypes. [1]. Nature doi:10.1038/nature16971
- Peça J, Feliciano C, Ting JT, Wang W, Wells MF, Venkatraman TN, Lascola CD, Fu Z, Feng G. (2012) Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature 472: 437–442
- Welch, JM., Lu, J., Rodriguiz, RM., Trotta, NC., Peca, J., Ding, J-D., Feliciano, C., Chen, M., Adams, JP., Luo, J., Dudek, SM., Weinberg, RJ., Calakos, N., Wetsel, WC., and Feng, G. (2007) Cortico-striatal synaptic defects and OCD-like behaviors in SAPAP3 mutant mice. Nature 448: 894–900
- Feng G et al. (2000) Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP. Neuron 28: 41–51
References
- ^ "Guoping Feng". Arnold and Mabel Beckman Foundation. Retrieved 1 August 2018.
- ^ http://newsinfo.iu.edu/news-archive/23076.html
- ^ McGovern Institute: Guoping Feng (accessed 6 February 2016)
- ^ MIT: Feng, Guoping (accessed 6 February 2016)
- ^ http://www.nature.com/nature/journal/v448/n7156/full/7156xiiia.html
- ^ https://www.sciencedaily.com/releases/2012/10/121017131843.htm
- ^ http://www.nih.gov/news-events/news-releases/gene-triggers-obsessive-compulsive-disorder-syndrome-mice
- ^ http://www.nature.com/nature/journal/v448/n7156/full/7156xiiia.html
- ^ http://cen.acs.org/articles/90/i10/Inner-Workings-Autism.html
- ^ http://news.mit.edu/2015/shank3-gene-autism-schizophrenia-1210
- ^ http://www.ibtimes.co.uk/autism-behaviours-reversed-mice-by-switching-shank3-gene-adulthood-1544661
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