H1FNT

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H1 histone family, member N, testis-specific
Identifiers
Symbol H1FNT
Alt. symbols HANP1, H1T2
Entrez 341567
HUGO 24893
RefSeq NM_181788
UniProt Q75WM6
Other data
Locus Chr. 12 q13.11

H1 histone family, member N, testis-specific is a member of the histone family of nuclear proteins which are a component of chromatin. In humans, this protein is encoded by the H1FNT gene.[1]

The H1FNT protein is essential for nuclear formation in spermatozoa, and is involved in the replacement of histones with protamines during spermiogenesis.[2]

References[edit]

  1. ^ Martianov I, Brancorsini S, Catena R, et al. (February 2005). "Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesis". Proceedings of the National Academy of Sciences of the United States of America. 102 (8): 2808–13. doi:10.1073/pnas.0406060102. PMC 549447Freely accessible. PMID 15710904. 
  2. ^ Tanaka H, Matsuoka Y, Onishi M, Kitamura K, Miyagawa Y, Nishimura H, Tsujimura A, Okuyama A, Nishimune Y (April 2006). "Expression profiles and single-nucleotide polymorphism analysis of human HANP1/H1T2 encoding a histone H1-like protein". International journal of andrology. 29 (2): 353–9. doi:10.1111/j.1365-2605.2005.00600.x. PMID 16533358. 

External links[edit]