HIST1H4J
Template:PBB Histone cluster 1, H4j is a protein that in humans is encoded by the HIST1H4J gene.[1]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008].[1]
References
- ^ a b "Entrez Gene: Histone cluster 1, H4j". Retrieved 2012-03-12.
Further reading
- Deng, L.; De La Fuente, C.; Fu, P.; Wang, L.; Donnelly, R.; Wade, J. D.; Lambert, P.; Li, H.; Lee, C. G.; Kashanchi, F. (2000). "Acetylation of HIV-1 Tat by CBP/P300 Increases Transcription of Integrated HIV-1 Genome and Enhances Binding to Core Histones". Virology. 277 (2): 278–295. doi:10.1006/viro.2000.0593. PMID 11080476.
- Deng, L.; Wang, D.; De La Fuente, C.; Wang, L.; Li, H.; Lee, C. G.; Donnelly, R.; Wade, J. D.; Lambert, P.; Kashanchi, F. (2001). "Enhancement of the p300 HAT Activity by HIV-1 Tat on Chromatin DNA". Virology. 289 (2): 312–326. doi:10.1006/viro.2001.1129. PMID 11689053.
- Marzluff, W. F.; Gongidi, P.; Woods, K. R.; Jin, J.; Maltais, L. J. (2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–498. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
- Lusic, M.; Marcello, A.; Cereseto, A.; Giacca, M. (2003). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". The EMBO Journal. 22 (24): 6550–6561. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.
- Heintz, N.; Zernik, M.; Roeder, R. G. (1981). "The structure of the human histone genes: Clustered but not tandemly repeated". Cell. 24 (3): 661–668. doi:10.1016/0092-8674(81)90092-1. PMID 6265100.
- Albig, W.; Doenecke, D. (1997). "The human histone gene cluster at the D6S105 locus". Human Genetics. 101 (3): 284–294. doi:10.1007/s004390050630. PMID 9439656.
- El Kharroubi, A.; Piras, G.; Zensen, R.; Martin, M. A. (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Molecular and Cellular Biology. 18 (5): 2535–2544. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.
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