HLA-Cw4

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HLA-Cw4
(MHC Class I, C cell surface antigen)
HLA-Cw4.png
HLA-Cw4
-
Protein transmembrane receptor/ligand
Structure αβ heterodimer
Subunits HLA-Cw*04--, β2-microglobulin
Older names "-"
-
subtype allele Available structures
Cw4 *0401
rare alleles
Cw403 *0403
Alleles link-out to IMGT/HLA database at EBI

HLA-Cw4 (Cw4) is a human leukocyte antigen serotype within HLA-C serotype group. The serotype is determined by the antibody recognition of α4 subset of HLA-Cw α-chains. For Cw4, the alpha chain are encoded by the HLA-Cw*04 allele group and the β-chain are encoded by B2M locus.[1] Cw4 and Cw*04 are almost synonymous in meaning.

Further information: HLA serotypes explained

Cw4 is more common in SE Europe. Cw4 in Europe is part of the Cw4-B35 haplotype.

Serotype[edit]

Cw4 recognition of some HLA Cw*04 gene products[2]
Cw*04 Cw4 Cw403 Cw6 Sample
allele  %  %  % size (N)
*0401 98 0 0 736
*0403 37 5 17 25



Alleles[edit]

HLA Cw*0401 frequencies
Study population Freq.
 (in %)[3]
Mexico Mixe Oaxaca 37.8
Mexico Mixtec Oaxaca 37.3
USA N. Mexico Canoncito N… 31.7
Mexico Zaptotec Oaxaca 30.6
Iran Baloch 28.6
Australia Indig. Cape Yor… 27.5
Australia Indig.Yuendumu 26.8
Australia Indig. Groote E… 25.3
Lebanon 24.3
Israel Arab Druse 22.5
Georgia Tibilisi Kurds 22.4
Brazil Terena 22.3
Georgia Tibilisi Georgian… 22.0
India Tamil Nadu Nadar 21.3
Mali Bandiagara 21.3
Taiwan Ami 20.9
Papua New Guinea Wanigela 20.8
USA African Americans pop… 19.6
Senegal Niokholo Mandenka 19.5
Cameroon Beti 18.7
Indig. Australian Kimberl… 17.9
Papua New Guinea Wosera 17.0
Italy North pop 1 16.7
New Caledonia 16.7
Morocco Nador Metalsa (be… 15.9
Portugal Centre pop 2 15.8
Cameroon Sawa 15.4
India Mumbai Marathas 15.4
Iran Tehran 15.4
USA Hispanic 15.0
PNG West Schrader Ranges 14.8
Zimbabwe Harare Shona 14.8
Swiss Geneva 14.5
Zambia Lusaka 14.4
Uganda Kampala 14.1
Brazil 13.7
Sudanese 13.5
France West 13.4
Tibetan 13.3
Finland 13.3
Kenya Luo 13.2
Cameroon Bamileke 13.0
Philippines Ivatan 13.0
Kenya 12.9
Singapore Riau Malay 12.2
India North Delhi 11.7
Tunisia 11.6
Kenya Nandi 11.5
Russia Tuva pop 2 11.5
Taiwan Bunun 11.4
USA Caucasian pop2 11.1
India West Coast Parsis 11.0
China Qinghai Hui 10.9
Czech Republic 10.8
India New Delhi 10.7
Spain Eastern Andalusia 10.4
UK Caucasians 10.1
Cameroon Pygmy Baka 10.0
China Beijing 10.0
Jordan Amman 10.0
Singapore Javanese 10.0
Papua New Guinea Madang 9.5
Saudi Arabia Guraiat and … 9.5
Australia New South Wales 9.4
USA Alaska Yupik Natives 9.3
Bulgaria Gipsy 9.1
Mex. Chihuahua Tarahumara 9.1
German Essen 9.0
France South East 8.9
Taiwan Paiwan 8.8
China Inner Mongolia 8.3
Ireland Northern 8.3
Venezuela Perija Yucpa 8.3
South Korea (1) 8.2
China North Han 7.6
USA South Dakota Lakota S… 7.4
Taiwan Atayal 7.1
India West Bhils 7.0
PNG Karimui Plateau 6.9
Taiwan Siraya 6.9
Taiwan Thao 6.7
Japan (5) 6.5
Thailand 6.0
China Guangzhou 5.6
USA Asian 5.6
Ireland South 5.4
PNG Eastern Highlands Gor… 4.7
Japan Central 4.6
Spain Eastern Andalusia G… 4.5
China South Han 4.4
South Africa Natal Tamil 4.2
American Samoa 4.0
Taiwan Saisiat 3.9
Papua New Guinea New Brit… 3.6
Taiwan Minnan pop 1 3.4
USA Hawaii Okinawa 3.3
China Guangdong Meizhou H… 3.0
India Khandesh Pawra 3.0
Taiwan Puyuma 3.0
Allele frequencies presented, only
HLA Cw*0403 frequencies
Study population Freq.
 (in %)[3]
PNG West Schrader Ranges 45.9
Taiwan Tao 40.0
PMG Eastern Highlands Gor… 34.9
PNG Madang 25.0
PNG Wanigela 16.0
Australia Indig. Cape Yor… 15.7
Australia Indig. Yuendumu 15.1
Australia Indig. Groote E… 12.3
Taiwan Puyuma 12.0
PNG Karimui Plateau 11.9
Taiwan Pazeh 11.8
Taiwan Thao 11.7
New Caledonia 11.1
Singapore Riau Malay 9.8
PNG New Britain Rabaul 8.9
PNG Wosera 8.0
Singapore Javanese 7.0
Taiwan Rukai 7.0
Taiwan Bunun 6.4
American Samoa 6.0
Thailand 5.3
Philippines Ivatan 5.0
Taiwan Siraya 4.9
Taiwan Tsou 4.9
Australia Indig. Kimberly 3.6
Taiwan Atayal 3.3
South Africa Natal Tamil 3.1
Taiwan Ami 2.6
China South Han 2.1
USA Asian 2.0
Taiwan Hakka 1.8
China Qinghai Hui 1.4
Iran Tehran 1.3
China Guangdong Meizhou H… 1.0
China Inner Mongolia 1.0
India West Coast Parsis 1.0
Taiwan Minnan pop 1 1.0
Taiwan Paiwan 1.0
India New Delhi 0.9
Russia Tuva 0.9
China Tibetan 0.6
Allele frequencies presented, only

References[edit]

  1. ^ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067. 
  2. ^ Allele Query Form IMGT/HLA - European Bioinformatics Institute
  3. ^ a b Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.