HLA-DR18

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Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen
major histocompatibility complex, class II, DR18
Haplotypes groups DRA*01:DRB1*0302 DRA*01:DRB5*0303
Structure (See HLA-DR)
Identifiers
alpha *0101
Symbol(s) HLA-DRA
EBI-HLA DRA*0101
Identifiers
beta 1 *0302 *0303
Symbol(s) HLA-DRB1
EBI-HLA DRB5*0302
EBI-HLA DRB1*0303
Shared data
Locus chr.6 6p21.31

HLA-DR18 (DR18) is a HLA-DR serotype that recognizes the DRB1*0302 and *0303 gene products. Compared to DR17 which is found at high frequency in Western Europe, DR18 is found more in SE Europe and Central Asia.

Serology[edit]

DR18 recognition of some DRB1*03 alleles[1]
DRB1* DR18 DR3 DR17 Sample
allele  %  %  % size (N)
0302 66 24 3 317
0303 60 40 5

DR18 recognizes the DRB1*0302 and *0303, the thoroughness of recognition is fair, but better than DR3.

Disease associations[edit]

DR18 seropositivity is associated with rheumatoid polyarthritis[2]

DRB1*0302 is positively associated with juvenile diabetes,[3] nuclear helicase Mi-2 autoantibodies in inflammatory inclusion body myositis.[4]

Genetic Linkage[edit]

DR18 Haplotypes
Serotypes DRA DRB1 DRB3
DR18(3)-DR52 *0101 *0302 *0101
DQA1 DQB1 DRB1
D18(3)-DQ2(2.5) *0501 *0201 *0302
HLA-A HLA -B DRB1
A33-B58-DR18(3) *3301 *5801 *0302

HLA-DR18 is genetically linked to DR52 and HLA-DQ2 serotypes. These serotypes are the result of gene products from the HLA-DRB3* and HLA DQA1*0501 and HLA DQB1*0201 alleles.

References[edit]

  1. ^ derived from IMGT/HLA
  2. ^ Dieye A, Diallo S, Diatta M, Thiam A, Ndiaye R, Bao O, Sarthou J (1997). "[Identification of HLA-DR alleles for susceptibility to rheumatoid polyarthritis in Senegal]". Dakar Med. 42 (2): 111–3. PMID 9827131. 
  3. ^ Shawkatova I, Michalkova D, Barak L, Fazekasova H, Kuba D, Buc M (2006). "HLA class II allele frequencies in type 1A diabetes mellitus Slovak patients". Bratislavské lekárske listy. 107 (3): 76–9. PMID 16796128. 
  4. ^ Sivakumar K, Semino-Mora C, Dalakas MC (1997). "An inflammatory, familial, inclusion body myositis with autoimmune features and a phenotype identical to sporadic inclusion body myositis. Studies in three families". Brain. 120 ( Pt 4) (4): 653–661. PMID 9153127. doi:10.1093/brain/120.4.653.