HLA-DR2
HLA-DR2 (DR2) of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group. This serotype primarily recognizes gene products of the HLA-DRB1*15 and HLA-DRB1*16 allele groups.
Serology
| DRB1* | DR15 | DR2 | DR16 | Sample |
| allele | % | % | % | size (N) |
| 1501 | 76 | 23 | 6428 | |
| 1502 | 77 | 16 | 676 | |
| 1503 | 81 | 13 | 286 | |
| 1504 | >50 | 1 | ||
| 1505 | >25 | 2 | ||
| 1507 | >50 | 1 | ||
| . | ||||
| DR16 | DR2 | DR15 | N | |
| 1601 | 41 | 29 | 19 | 703 |
| 1602 | 47 | 30 | 16 | 239 |
| 1604 | >50 | 1 |
Disease associations
DR2 serotypes are associated with Goodpasture syndrome, systemic lupus erythematosus, multiple sclerosis,[2] and narcolepsy, tuberculoid leprosy[3] (multi-drug resistant tuberculosis or leprosy),[4] ulcerative colitis(Japanese),[5] primary biliary cirrhosis and autoimmune hepatitis.[6] DR2 is also found in all patients that test positive for anti-anti-Asn-RNA-synthetase and chronic interstitial lung disease.[7]
Genetic linkage
DR2 is linked to the HLA-DR53.
References
- ^ derived from IMGT/HLA
- ^ Stewart G, McLeod J, Basten A, Bashir H (1981). "HLA family studies and multiple sclerosis: A common gene, dominantly expressed". Hum Immunol. 3 (1): 13–29. doi:10.1016/0198-8859(81)90040-9. PMID 7275697.
- ^ van Eden W, de Vries R, Mehra N, Vaidya M, D'Amaro J, van Rood J (1980). "HLA segregation of tuberculoid leprosy: confirmation of the DR2 marker". J Infect Dis. 141 (6): 693–701. doi:10.1093/infdis/141.6.693. PMID 6156220.
- ^ Singh M, Balamurugan A, Katoch K, Sharma SK, Mehra NK (2007). "Immunogenetics of mycobacterial infections in the North Indian population". Tissue Antigens. 69 Suppl 1: 228–30. doi:10.1111/j.1399-0039.2006.77311.x. PMID 17445206.
- ^ Asakura H, Tsuchiya M, Aiso S, Watanabe M, Kobayashi K, Hibi T, Ando K, Takata H, Sekiguchi S (1982). "Association of the human lymphocyte-DR2 antigen with Japanese ulcerative colitis". Gastroenterology. 82 (3): 413–8. PMID 6947923.
- ^ Miyamori H, Kato Y, Kobayashi K, Hattori N (1983). "HLA antigens in Japanese patients with primary biliary cirrhosis and autoimmune hepatitis". Digestion. 26 (4): 213–7. doi:10.1159/000198892. PMID 6409699.
- ^ Hirakata M, Suwa A, Takada T, et al. (2007). "Clinical and immunogenetic features of patients with autoantibodies to asparaginyl-transfer RNA synthetase". Arthritis Rheum. 56 (4): 1295–303. doi:10.1002/art.22506. PMID 17393393.