HLR may refer to:
- Hall Road railway station, in England, National Rail station code
- Heli Air Services, Bulgaria, ICAO code
- Home location register, a GSM subscriber database
- Hong Lok Road stop, Hong Kong, MTR station code
- Hood Army Airfield, in Texas, US, ICO and FAA LID code
- The Human Life Review, an anti-abortion publication.
- Human Lunar Return study