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Heterogeneous nuclear ribonucleoprotein A/B
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM602688 MGI1330294 HomoloGene74950 GeneCards: HNRNPAB Gene
RNA expression pattern
PBB GE HNRPAB 201277 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3182 15384
Ensembl ENSG00000197451 ENSMUSG00000020358
UniProt Q99729 Q99020
RefSeq (mRNA) NM_004499 NM_001048061
RefSeq (protein) NP_004490 NP_001041526
Location (UCSC) Chr 5:
178.2 – 178.21 Mb
Chr 11:
51.6 – 51.61 Mb
PubMed search [1] [2]

Heterogeneous nuclear ribonucleoprotein A/B, also known as HNRPAB, is a protein which in humans is encoded by the HNRPAB gene.[1] Although this gene is named HNRNPAB in reference to its first cloning as an RNA binding protein with similarity to HNRNP A and HNRNP B,[2] it is not a member of the HNRNP A/B subfamily of HNRNPs, but groups together closely with HNRNPD/AUF1 and HNRNPDL.[3][4]


This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[1]


HNRPAB has been shown to interact with TP63.[5]


  1. ^ a b "Entrez Gene: HNRPAB heterogeneous nuclear ribonucleoprotein A/B". 
  2. ^ Khan FA, Jaiswal AK, Szer W (September 1991). "Cloning and sequence analysis of a human type A/B hnRNP protein". FEBS Lett. 290 (1-2): 159–61. doi:10.1016/0014-5793(91)81249-8. PMID 1717314. 
  3. ^ Akindahunsi AA, Bandiera A, Manzini G (February 2005). "Vertebrate 2xRBD hnRNP proteins: a comparative analysis of genome, mRNA and protein sequences". Comput Biol Chem 29 (1): 13–23. doi:10.1016/j.compbiolchem.2004.11.002. PMID 15680582. 
  4. ^ Czaplinski K, Köcher T, Schelder M, Segref A, Wilm M, Mattaj IW (April 2005). "Identification of 40LoVe, a Xenopus hnRNP D family protein involved in localizing a TGF-beta-related mRNA during oogenesis". Dev. Cell 8 (4): 505–15. doi:10.1016/j.devcel.2005.01.012. PMID 15809033. 
  5. ^ Fomenkov, Alexey; Huang Yi-Ping; Topaloglu Ozlem; Brechman Anna; Osada Motonobo; Fomenkova Tanya; Yuriditsky Eugene; Trink Barry; Sidransky David; Ratovitski Edward (Jun 2003). "P63 alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay-Wells syndrome". J. Biol. Chem. (United States) 278 (26): 23906–14. doi:10.1074/jbc.M300746200. ISSN 0021-9258. PMID 12692135. 

Further reading[edit]