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Hans Kuhn (chemist)

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Hans Kuhn
Hans Kuhn *1919 in 1975
Born5 December 1919
Died25 November 2012 (2012-11-26) (aged 92)

Hans Kuhn (5 December 1919 – 25 November 2012) was a Swiss chemist. He was professor emeritus for physical chemistry and former scientific director at the Max Planck Institute for Biophysical Chemistry (Karl Friedrich Bonhoeffer Institute) in Göttingen.[1][2]

Biography

Curriculum

Hans Kuhn was born in Berne, Switzerland. He studied chemistry at the ETH Zürich and worked for his doctorate at University of Basel under the guidance of Werner Kuhn (not related). He received his habilitation in 1946. From 1946 until 1947 he worked as a post doctoral fellow with Linus Pauling at Caltech in Pasadena and in 1950 with Niels Bohr in Copenhagen. In 1951, he became professor at the University of Basel. He was appointed in 1953 as professor and director of the Institute of Physical Chemistry of the Philipps University of Marburg where he stayed until 1970. Then he was at the Max Planck Institute for Biophysical Chemistry (Karl Friedrich Bonhoeffer Institute) in Göttingen as director of the department 'Molecular Systems Assembly' until his retirement 1985.

Fritz Peter Schäfer, Peter Fromherz, Horst-Dieter Försterling, Viola Vogel and Dietmar Möbius were among Kuhn's students. Erwin Neher was member in his department 'Molecular Systems Assembly'.

Kuhn married Elsi Hättenschwiler 1948. Their four children were Elisabeth, Andreas, Eva and Christoph. Elsi died 2004.

Scientific research

Kuhn began to work for his doctorate by investigating decoiling of a random coiled chain molecule in a flowing viscous solvent. Werner Kuhn suggested him to replace the random coil by a dumbbell-model. Kuhn was fascinated by the model's simplicity and by its great success in theoretically analyzing a broad variety of experiments in quantitative terms. This experience and his postdoctoral work with Linus Pauling and Niels Bohr, supported this fascination for powerful simple models and was determining for his life's work in research.[3]

Polymer molecules were described as chains of statistical chain elements.[4] The preferential statistical elements were defined in 1943.[5] Today the preferential element is called Kuhn length, in the recent textbook Principles of Physical Chemistry it is simply called statistical chain element.[6] Kuhn made experiments with macroscopic models of random coils to describe the behavior in flowing liquids more accurately than based on the dumbbell-model.[7]

Polyene: potential energy (troughs of the nuclear shells neglected) and π-electron density. a) Instability of equal bonds. b) Stabilized by alternation of single and double bonds (bond length consistent with π-electron density (BCD)-approximation).

In Pauling's lab, Kuhn was trying to understand the color of polyenes by describing π-electrons as particles in a box and he was greatly disappointed - it did not work. Later, when applying the model to cyanine dyes he observed a quantitative agreement with experiment.[8] Today the model is called free electron model (FEMO). He saw the reason why he had failed in polyenes: an instability when assuming equal bonds leads to an alternation between single- and double-bonds caused by the condition of self-consistency between bond length and π-electron density distribution. He justified this assumption by finding agreement between measured and theoretically predicted absorption spectra.[9] Later this assumption was theoretically verified.[10] This effect is often called Peierls instability: starting from a linear chain of equally spaced atoms Peierls considered first order perturbation theory with Bloch wave functions showing the instability, but he did not consider the self-consistency resulting in the transition to alternation of single and double bonds.[11][12][13][14] The particular properties of conducting polymers are based on the theoretical relation between bond alternation and equalization. The FEMO and its improvements led to a theory on the light absorption of organic dyes.[15][16] In Marburg, shortly before the age of digital computers, Kuhn and Fritz Peter Schäfer developed an analogue computer to solve the 2-dimensional Schrödinger equation.[17] This room-filling analogue computer was applied by Kuhn's research group to calculate bond lengths in π-electron systems.[10][15][18][19][20][21][22]

Separating and contacting (from a to b and from b to c) in atomic precision. Monolayer of a blue fluorescent dye (donor) on a glass slide partially covered by a monolayer of a red fluorescent dye (acceptor) fixed at a PVA-polymer layer. Energy transfer from donor to acceptor at contact.[23] Courtesy Dietmar Möbius. Reproduced with permission, Wiley-VCH Verlag
(a) Modeling emergence of first replicating strand (oligomer R). (b) Very particular location on the prebiotioc planet. Arrow: small region, very particular cyclic change of temperature and many other special conditions given by chance just here. (c) Evolution of increasingly complex self-reproducing forms by populating increasingly unfavorable regions.

In the beginning of the 1960s, Kuhn thought about a new paradigm in chemistry: the synthesis of different molecules which fit structurally into each other in such a way that they form planned functional units (supramolecular machines).[24] His research group constructed simple prototypes of supramolecular functional units by advancements of the Langmuir–Blodgett films.[25][26] Such films are known today under the name Langmuir–Blodgett-Kuhn-films (LBK-films) or Langmuir–Blodgett-Kuhn-(LBK)-layers. The many different techniques to manipulate systems of monolayers were developed in close cooperation of Kuhn and Dietmar Möbius. Thus the layers should be called Langmuir–Blodgett-Möbius-Kuhn (LBMK)-layers.

In close correspondence to the objective of constructing supramolecular functional units he (now at the Max Planck Institute for Biophysical Chemistry in Göttingen) approached theoretically the origin of life: modelling a hypothetical chain of many small physical-chemical steps that leads to the genetic apparatus. Some steps are of particular significance, such as the step initiating the transition from a multiplication and translation apparatus into a multipilcation, transcription and translation apparatus.[27][28][29][30][31][32][33] This genetic apparatus agrees in the basic structure and in the mechanism with the biological multiplication and translation apparatus. The skill of the experimentalist building supramolecular machines is replaced in life's origin by very particular conditions given by chance in a very particular location on the prebiotic earth and elsewhere in the universe driving the process.

The unifying paradigm has led to construct supramolecular machines and to invent a pathway leading to an apparatus based on the same mechanism as the genetic apparatus of bio-systems. This required thinking in terms of strongly simplifying theoretical models describing complex situations. Important new methods were invented and developed in several laboratories. This caused a divergence - supramolecular chemistry, molecular electronics, Systems chemistry and important contributions to nano-technology.[34] [35] [36] [37] Future research will be based on integrating these topics. Having in mind this coherence is stimulating and will be useful. In Kuhn's view these challenging topics should be included in a modern textbook on physical chemistry.

During his retirement, Kuhn developed (with his son Christoph and with Horst Dieter Försterling) his early work on π-electron density (a precursor of the Density functional theory (DFT)) to a very useful approximation called BCD method (bondlength consistent with total π-electron density method). He contributed in understanding Photosynthesis of Purple bacteria, the proton pump of Halobacterium, and the ATP synthase motor.[6]

Honours and awards

The items of this list are accessible.[38]

Bibliography

  • The Electron Gas Theory of the Color of Natural and Artificial Dyes. by Hans Kuhn in Progress in the Chemistry of Organic Natural Products ed. Laszlo Zechmeister 16, 169 (1958) and ibid. 17, 404 (1959).
  • Praxis der Physikalischen Chemie. Grundlagen, Methoden, Experimente by Horst-Dieter Försterling and Hans Kuhn, 3rd Edition, Wiley-VCH, Weinheim (1991) (ISBN 3-527-28293-9).
  • Monolayer assemblies. In Investigations of Surfaces and Interfaces by Hans Kuhn and Dietmar Möbius in Physical Methods of Chemistry Series eds. Bryant William Rossiter and Roger C. Baetzold, Part B, Chapter 6, Vol. 9B, 2nd Edition, Wiley, New York (1993).
  • Principles of Physical Chemistry by Hans Kuhn, Horst-Dieter Försterling and David H. Waldeck, 2nd Edition, Wiley, Hoboken (2009) (ISBN 978-0-470-08964-4)

References

  1. ^ History of the Max Planck Institut for Biophysical Chemistry in Göttingen. Archived 2007-02-11 at the Wayback Machine
  2. ^ "Max-Planck-Institut für biophysikalische Chemie | Service | Presse- und Öffentlichkeitsarbeit | Pressemitteilungen | Trauer um Max-Planck-Direktor Hans Kuhn". Mpibpc.mpg.de. Retrieved 2012-12-09.
  3. ^ H. Kuhn: Fascination in Modeling Motifs, Chapter 6 in R. Jaenicke and G. Semanza (Eds.) Selected Topics in History of Biochemistry: Personal Recollections VI (Comprehensive Biochemistry Vol 41) Elsevier Science 2000.
  4. ^ W. Kuhn: Ueber die Gestalt fadenförmiger Moleküle in Lösungen Kolloid Zeitschrift 68:2 (1934).
  5. ^ W. Kuhn and H. Kuhn: Die Frage nach der Aufrollung von Fadenmolekülen in strömenden Lösungen Helv. Chim. Acta 26:1394 (1943).
  6. ^ a b Principles of Physical Chemistry by Hans Kuhn, Horst-Dieter Försterling and David H. Waldeck, 2nd Edition, Wiley, Hoboken (2009)
  7. ^ H. Kuhn: Viscosity, sedimentation, and diffusion of long-chain molecules in solution as determined by experiments on large scale models. J. Colloid Sci. 5:331 (1950).
  8. ^ H. Kuhn: Elektronengasmodell zur quantitativen Deutung der Lichtabsorption von organischen Farbstoffen J. Helv. Chim. Acta 31:1441 (1948).
  9. ^ H. Kuhn: A quantum mechanical theory of light absorption of organic dyes and similar compound J. Chem. Phys. 17:1198 (1949).
  10. ^ a b F. Bär, W. Huber, G. Handschig, H. Martin and H. Kuhn: "Nature of the free electron gas model. The case of the polyenes and polyacetylenes." J. Chem. Phys. 32, 470 (1960).
  11. ^ R. E. Peierls: Zur Theorie der elektrischen und thermischen Leitfähigkeit von Metallen Ann. Phys. 4:121-148 (1930).
  12. ^ R. E. Peierls: Quantum theory of solids Clarendon, Oxford (1955).
  13. ^ R. E. Peierls: Surprises in Theoretical Physics Princeton University Press, Princeton (1979), p73.
  14. ^ R. E. Peierls: More Surprises in Theoretical Physics Princeton University Press, Princeton (1991) p.29.
  15. ^ a b H. Kuhn: The Electron Gas Theory of the Color of Natural and Artificial Dyes'. Progress in the Chemistry of Organic Natural Products (L.Zechmeister ed.) 16:169 (1958) and ibid. 17:404 (1959).
  16. ^ H. Kuhn: Neuere Untersuchungen über das Elektronengasmodell organischer Farbstoffe. Werner Kuhn, Basel, zum 60. Geburtstag gewidmet. Angew. Chem. 71:93–101 (1958).
  17. ^ F.P. Schäfer: "Analogrechner und Registrierautomat zur Ermittlung der stationären Wellenfunktionen und Energieniveaus eines Teilchens in einem zweidimensionalen Potentialfeld", Dissertation Marburg (1960).
  18. ^ H. Kuhn, W. Huber, G. Handschig, H. Martin, F. Schäfer, and F. Bär: "Nature of the Free Electron Model. The Simple Case of the Symmetric Polymethines." J. Chem. Phys., 32, 467 (1960)
  19. ^ H. Kuhn: Analogiebetrachtungen und Analogrechner zur quantenmechanischen Behandlung der Lichtabsorption der Farbstoffe Archived 2008-07-04 at the Wayback Machine Chimia 15:53-62 (1961)
  20. ^ F. F. Seelig, W. Huber, H. Kuhn: Analogiebetrachtungen und Analogrechner zur Behandlung der Korrelation von π-Elektronen Archived 2008-07-04 at the Wayback Machine Zeitschrift für Naturforschung 17a:114–121 (1962).
  21. ^ H.D. Försterling, W. Huber and H. Kuhn: Projected electron density method of π-electron systems I. Electron distribution in the ground state. Int. J. Quant. Chem. 1, 225 (1967).
  22. ^ H.D. Försterling and H. Kuhn: "Projected electron density method of π-electron systems II. Excited states." Int. J. Quant. Chem. 2, 413 (1968).
  23. ^ D. Möbius: "Manipulieren in molekularen Dimensionen" Chemie in unserer Zeit 9:173-182 (1975).
  24. ^ H. Kuhn: "Versuche zur Herstellung einfacher organisierter Systeme von Molekülen" Verhandlungen der Schweizerischen Naturforschenden Gesellschaft, 245–66 (1965)
  25. ^ H. Bücher, K.H. Drexhage, M. Fleck, H. Kuhn, D. Möbius, F.P. Schäfer, J. Sondermann, W. Sperling, P. Tillmann and J. Wiegand: "Controlled transfer of excitation energy through thin layers", Molecular Crystals 2:199 (1967)
  26. ^ H. Kuhn, D. Möbius: "Systems of monomolecular layers-assembling and physico-chemical properties" Angew. Chem. Int. Ed. Engl, 10:620–37 (1971).
  27. ^ H. Kuhn: "Self-organization of molecular systems and evolution of the genetic apparatus", Angew. Chem. Int. Ed. Engl. 11:798–820 (1972)
  28. ^ H. Kuhn: "Model consideration for the origin of life. Environmental structure as stimulus for the evolution of chemical systems", Naturwissenschaften 63:68–80 (1976)
  29. ^ H. Kuhn, J. Waser: "Molecular self-organization and the origin of life", Angew. Chem. Int. Ed. Engl. Edit. 20:500–20 (1981).
  30. ^ H. Kuhn, J. Waser: "A model of the origin of life and perspectives in supramolecular engineering" in: J.-P.Behr (editor): "Lock-and-key principle", Chichester: Wiley 247–306 (1994)
  31. ^ H. Kuhn, C. Kuhn: "Diversified world: drive of life's origin?!", Angew. Chem. Int Ed. Engl. 42:262–6 (2003)
  32. ^ H. Kuhn: "Origin of life — Symmetry breaking in the universe: Emergence of homochirality" Current Opinion in Colloid & Interface Science 13:3–11 (2008).
  33. ^ H. Kuhn: "Is the transition from chemistry to biology a mystery?" Systems Chemistry 1:3 (2010).
  34. ^ J.-M.Lehn "Supramolecular Chemistry: Concepts and Perspectives." Wiley-VCH, Weinheim (1996)
  35. ^ M. Elbing, R. Ochs, M. Koentopp, M.Fischer, C. von Hänisch, F. Weigand, F. Evers, H.B. Weber, M. Mayor. "A single-molecule diode." PNAS 102, 8815-8820 (2005).
  36. ^ M. Kindermann, I. Stahl, M. Reimold, W. M. Pankau, G. von Kiedrowski "Systems chemistry: kinetic and computational analysis of a nearly exponential organic replicator." Angew. Chem. Int. Ed. Engl. 44, 6750-6755 (2005).
  37. ^ H. Hess, G. D. Bachand, V. Vogel "Powering Nanodevices with Biomolecular Motors." Chem. Eur. J. 10, 2110-2116 (2004).
  38. ^ items of awards
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