Seyffer was born in Sinsheim. Little else is known about his life. He lived and worked at a dramatic turn of an era (from late Gothic to Renaissance) together with other masters (e.g. Tilman Riemenschneider, Veit Stoss and Hans Brueggemann). He created many well-known works of art in Heilbronn and Stuttgart (both in Germany). He died in Heilbronn.