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Harriette Chick

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Harriette Chick, 1907

Dame Harriette Chick, DBE (6 January 1875 – 9 July 1977) was a British microbiologist, protein scientist and nutritionist. She is best remembered for demonstrating the roles of sunlight and cod liver oil in preventing rickets.

Early life and education

She was born into a Methodist family, the sixth child of twelve and one of seven daughters who survived beyond infancy.[1] Her father, Samuel Chick, owned property and sold lace. The Chick children were brought up strictly with no frivolities and regular attendance at family prayers. All seven girls attended Notting Hill High school, a girls' school thought to be outstanding for its teaching in the sciences.[2] Subsequently six of the sisters including Harriette continued to study for university degrees.[2] Another of them, Frances, became a notable statistician.[3] While studying at University College London, Chick won awards for botany- the advanced-class prize in 1894–1895 and the senior-class Gold Medal in 1896.[4]

Early research on sewage disposal and mechanisms of disinfection

During the years 1898–1901 an award from the Royal Commission for the Exhibition of 1851 enabled her to undertake research with Prof Max von Gruber in the Institute for Hygiene in Vienna and with Prof Rubert Boyce in University College, Liverpool.[5] In 1902 she was appointed as assistant to Dr AC Houston, Chief Bacteriologist to the Royal Commission on Sewage Disposal.[6] In 1903 she returned to work with Gruber after his move to Munich in 1902. In 1904 she was awarded a DSc from London University for her work on green algae in polluted waters.[4] In 1905 at the suggestion of Charles Scott Sherrington she applied for the Jenner Memorial Research Studentship at the Lister Institute. Her application raised a number of objections as no woman had been bestowed the fellowship previously.[2] Her relationship with the Lister was long. Employed until 1945 with the institute, she was an honorary staff member thereafter for 25 years.

Harriette Chick in conservatory animal house at Roebuck House

Chick and Lister Institute director Charles James Martin discovered that the process of protein denaturation was distinct from protein coagulation (or flocculation),[7] beginning the modern understanding of protein folding. She is known for having formulated Chick's Law in 1908, giving the relationship between the kill efficiency of organisms and contact time with a disinfectant.[8][9] Chick's Law was later modified by Dr. H.E. Watson in 1908 to include the coefficient of specific lethality. The Chick-Watson Equation is still used. A new and, at the time, more realistic test for the effectiveness of disinfectants, the Chick-Martin test, was also devised and named for the two collaborators (see Phenol coefficient).

Experience as early woman scientist

In 1909 Chick was a cosignatory to a letter to The Times newspaper from a group of women graduates of the University of London calling for them to be allowed to vote for the Member of Parliament returned by their university.[10] In 1913 she was one of the first three women to be admitted to the Biochemical Society following its renaming and change of policy on the admission of women.[11]

Work at the Lister Institute during and immediately after the First World War: transition to nutritional studies

In 1915, she briefly went to the Lister Institute in Elstree to test and bottle tetanus antitoxin for the army.[12] She returned to the Chelsea building, however, to prepare agglutinating sera for diagnosis of typhoid and related diseases in troops. Subsequently, however, she commenced studies on rectifying nutritional deficiencies in the wartime diets of both the native population and overseas forces. Initially this involved surveys of the ability of various foodstuffs to counter scurvy and beriberi.[13] In 1919, together with Dr. Elsie Dalyell, she led a team, including Margaret Hume and Hannah Henderson Smith, from the Lister Institute and the Medical Research Council (United Kingdom) to study the relation of nutrition to childhood bone disease in post-war Vienna. They discovered the nutritional factor causing rickets, and proved that fat-soluble vitamins present in cod liver oil, or exposure to ultra violet light, could cure and prevent rickets in children.[14][15]

Chick was appointed Head of a new nutrition section at the Lister Institute and continued with her research on rickets and, additionally, pellagra. The department was relocated to the Cambridge house of the Lister director CJ Martin during the Second World War.

Honours and distinctions

She served as secretary of the League of Nations health section committee on the physiological bases of nutrition from 1934 to 1937. In 1941 she was a founding member of the Nutrition Society, of which she served as president from 1956 to 1959. She was appointed CBE in 1932 and subsequently DBE in 1949. In 1960 she received an honorary fellowship of the Royal Society of Medicine. In 1918 she was elected to the Physiological Society. She served as Secretary of the Accessory Food Factors Committee of the Medical Research Council from 1918–1945. She also acted as Secretary of the League of Nations Health Section Committee on the Physiological Bases of Nutrition from 1934–1937. Dr. Chick was also a founding member of the Nutrition Society in 1941. Later she was president of the Nutrition Society from 1956–1959. In 1949 she became Dame of the British Empire. <http://www.mc.vanderbilt.edu/diglib/sc_diglib/archColl/14.htmlf>

Death

She never married and died in 1977, aged 102.

References

  1. ^ "Charlotte Mew Chronology with mental, historical and geographical connections linking with her own words, and listing her essays, stories, poems and friends". Studymore.org.uk. Retrieved 28 March 2016.
  2. ^ a b c Creese, Mary (1998). Ladies in the Laboratory (1 ed.). Maryland: The Scarecrow Press. p. 149. ISBN 0-8108-3287-9.
  3. ^ Cole, Tim (9 October 2017), "The remarkable life of Frances Wood", Significance, [Royal Statistical Society]]
  4. ^ a b Haines, Catharine (2001). International Women in Science: A Biographical Dictionary to 1950. California: ABC-CLIO,Inc. ISBN 1-57607-090-5.
  5. ^ [1][dead link‍]
  6. ^ The Crusade Against Consumption. The Times, 13 January 1902 p6, London, England
  7. ^ Chick, Harriette; Martin, CJ (1910). "On the "Heat" Coagulation of Proteins". Journal of Physiology. 40: 404–430. doi:10.1113/jphysiol.1910.sp001378. PMC 1533708.
    Chick, Harriette; Martin, CJ (1911). "On the "Heat" Coagulation of Proteins; the Action of Hot Water upon Egg-albumen and the Influence of Acid and Salts upon Reaction Velocity". Journal of Physiology. 43: 1–27. doi:10.1113/jphysiol.1911.sp001456. PMC 1533708.
    Chick, Harriette; Martin, CJ (1912). "On the "Heat" Coagulation of Proteins. III. The Influence of Alkali upon Reaction Velocity". Journal of Physiology. 45: 61–69. doi:10.1113/jphysiol.1912.sp001535. PMC 1533708.
    Chick, Harriette; Martin, CJ (1912). "On the "Heat" Coagulation of Proteins. IV. The Conditions controlling the Agglutination of Proteins already acted upon by Hot Water". Journal of Physiology. 45: 261–95. doi:10.1113/jphysiol.1912.sp001551. PMC 1533708.
  8. ^ Chick's Law Archived 21 July 2015 at the Wayback Machine
  9. ^ "Women Physiologists". 308 (6937). 1994. PMC 2540130. {{cite journal}}: Cite journal requires |journal= (help)
  10. ^ L. Garrett Anderson, M. D., B.S., Marian Busk, B. S., Hon. Treasurer., & E. Honor Bone, M. D., B.S Harriette Chick, D.Sc. Jessie W. Scott. M.A. Hon. Secretaries. (16 November 1909). Women Graduates and the Suffrage. The Times, p. 12. London, England.
  11. ^ "Women in the Biochemical Society". .warwick.ac.uk. Retrieved 28 March 2016.
  12. ^ H. M. Sinclair, Chick, Dame Harriette (1875–1977) profile, Oxford Dictionary of National Biography, Oxford University Press, 2004; online edition, January 2008 accessed 19 Sept 2011
  13. ^ "Vitamin Discussion". Retrieved 12 November 2010.[dead link‍]
  14. ^ Information, Reed Business (28 July 1977). "New Scientist". {{cite journal}}: |first1= has generic name (help); Cite journal requires |journal= (help)
  15. ^ Dalyell and Chicks Research
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