Henrik Verder

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Henrik Verder
Born1942 (age 80–81)
Employer(s)Holbaek University Hospital, Denmark

Henrik Verder (born 1942) is a pediatrician and the inventor of the INSURE (Intubation Surfactant Extubation)and LISA (Less Invasive Surfactant Administration) methods combined with nasal CPAP (Continuous Positive Airway Pressure). In 1989 he used this pioneering method to successfully treat the first premature infant with severe RDS.[1] Verder is a significant researcher within the field of paediatrics, with more than 50 publications and over 500 citations.[2]


Verder received his medical degree from Copenhagen University in 1968 and went on to specialise in paediatrics in 1978, concentrating on prenatal determination of lung maturity and prevention of RDS (Infant Respiratory Distress Syndrome). In 1980 he was awarded his medical doctorate from Copenhagen University for his thesis on “Prenatal determination of lung maturity and prevention of RDS”.[3]


In 1972 Verder began his associated professorship at Copenhagen University where he went on to become a Professor of Paediatrics and Neonatology.[4] In 1989, at Holbaek Hospital, Verder was the first physician to successfully combine nasal CPAP and surfactant to treat an infant with severe RDS (28 weeks). This unique method was later named INSURE by Mats Blennow et al.[5] The full method was first published in 1992 along with the first documentation of infants treated with surfactant via a small diameter tube.[6] Egbert Herting has since described this method as ‘Less Invasive Surfactant Administration (LISA)’.[7] In addition surfactant administration via a laryngeal mask was described for the first time in 1992.[8] The introduction of CPAP in the treatment of RDS[9] more than halved the mortality rate of RDS – reducing mortality from an estimated 50% to 20%.[10] CPAP, when combined with the use of surfactant (INSURE),[11] halved the mortality rate once again, lowering it to approximately 10%. Early treatment of premature infants with RDS using the nasal CPAP and surfactant (INSURE) method is today considered the Global Gold standard of care.

Alongside his clinical achievements, Verder has also been actively involved in improving childcare and in 1975 he took the position of consultant for “Glostrup Observation Home” an institution for observation and treatment of neglected infants and toddlers.[12] In 1998 Verder began working with Professor Bo Sun at Fudan University, Shanghai, to improve neonatal care across China. As a part of this initiative he has visited more than 50 hospitals across 25 provinces and given lectures on the prevention and treatment of RDS, nutrition of pre-term and newborn infants and mother child attachment.[13][14][15][16][17] Alongside his contributions to Copenhagen University and his work in China, Verder also took the position of Co-chairman at Save the Children Denmark from 1990 to 1993. In this position, together with secretary-general Kristian Sørensen and lawyer Hanne Jensbo from Save the Children Denmark, he spearheaded the opening of Romanian orphanages after the fall of Ceaucescu in 1989. Verder was also involved in several initiatives, which supported the Romanian healthcare system.[18][19] In 2011 Verder became a member of the steering committee of “The Family Center” directed by Dr. May Olofsson, Hvidovre University Hospital, Copenhagen.[20] An organisation that treats infants and mothers suffering from sequelae, caused by alcohol and drug addiction during pregnancy.[21]

The INSURE Method[edit]

Verder is the inventor and pioneer of the INSURE method, a very effective approach to managing preterm neonates with respiratory distress. The method itself has been shown to successfully decrease the use of mechanical ventilation and lower the incidence of bronchopulmonary dysplasia (BPD).[22] Since its inception in 1989 the INSURE method has been academically cited in more than 500 papers.[23] The first randomised study on the INSURE method was published in 1994[24] and a second randomised study in infants less than 30 weeks gestation was published by the group in 1999.[25] In the last 15 years Verder has worked with lung maturity diagnostics on gastric aspirates obtained at birth. By combining this diagnostic method with INSURE, Verder has worked to further improve the clinical outcome of RDS. The lung maturity tests used have been the microbubble test,[26] lamellar body counts (LBC)[27] and measurements of lecithin-sphingomyelin ratio (L/S)[28] with chemometrics, involving a collaboration with Agnar Höskuldsson.[29]


  1. ^ Verder, H; Agertoft, L; Albertsen, P; Christensen, NC; Curstedt, T; Ebbesen, F; Greisen, G; Hobolth, N; Holm, V; Jacobsen, T (Jul 27, 1992). "[Surfactant treatment of newborn infants with respiratory distress syndrome primarily treated with nasal continuous positive air pressure. A pilot study]". Ugeskrift for Laeger. 154 (31): 2136–9. PMID 1509593.
  2. ^ "Henrik Verder research profile". www.Researchgate.net. Retrieved 15 July 2014.
  3. ^ "Thesis". Retrieved 15 July 2014.
  4. ^ "Henrik Verder research profile". www.Researchgate.net. Retrieved 15 July 2014.
  5. ^ Blennow, M; Jonsson, B; Dahlström, A; Sarman, I; Bohlin, K; Robertson, B (Mar 31, 1999). "[Lung function in premature infants can be improved. Surfactant therapy and CPAP reduce the need of respiratory support]". Läkartidningen. 96 (13): 1571–6. PMID 10218338.
  6. ^ Verder, H; Agertoft, L; Albertsen, P; Christensen, NC; Curstedt, T; Ebbesen, F; Greisen, G; Hobolth, N; Holm, V; Jacobsen, T (Jul 27, 1992). "[Surfactant treatment of newborn infants with respiratory distress syndrome primarily treated with nasal continuous positive air pressure. A pilot study]". Ugeskrift for Laeger. 154 (31): 2136–9. PMID 1509593.
  7. ^ Herting, E (Nov 2013). "Less invasive surfactant administration (LISA) - ways to deliver surfactant in spontaneously breathing infants". Early Human Development. 89 (11): 875–80. doi:10.1016/j.earlhumdev.2013.08.023. PMID 24075206.
  8. ^ Verder, Henrik (1992). treatment of RDS in spontaneously breathing premature infants with surfactant administered intratracheal thought laryngeal mask. Berlin u.a.: XIIIth European Congress of Perinatal Medicine : Amsterdam, May 12–15, 1992. p. 137. ISBN 3110136244.
  9. ^ Gregory, GA; Kitterman, JA; Phibbs, RH; Tooley, WH; Hamilton, WK (Jun 17, 1971). "Treatment of the idiopathic respiratory-distress syndrome with continuous positive airway pressure". The New England Journal of Medicine. 284 (24): 1333–40. doi:10.1056/NEJM197106172842401. PMID 4930602.
  10. ^ Verder, H (Apr 2007). "Nasal CPAP has become an indispensable part of the primary treatment of newborns with respiratory distress syndrome". Acta Paediatrica. 96 (4): 482–4. doi:10.1111/j.1651-2227.2007.00263.x. PMID 17391463. S2CID 30292433.
  11. ^ Morley, Colin; Gore, SheilaM.; Raju, TonseN.K.; Vidyasagar, Dharmapuri; Levy, PaulS. (1987). "Surfactants in Severe Hyaline Membrane Disease". The Lancet. 329 (8540): 1040–1041. doi:10.1016/S0140-6736(87)92316-6. S2CID 30443282.
  12. ^ "Glostrup's observational home". Retrieved 15 July 2014.
  13. ^ "Nordic Chinese Article on Verder's collaboration in China". Retrieved 30 July 2014.
  14. ^ "Hospital article on Verder's collaboration in China". Archived from the original on 8 August 2014. Retrieved 30 July 2014.
  15. ^ "Photo catalog on Verder's work in China". Archived from the original on 8 August 2014. Retrieved 30 July 2014.
  16. ^ "Article on Infant program in China". Archived from the original on 6 August 2014. Retrieved 30 July 2014.
  17. ^ "Chinese Article on Verder's work in China". Archived from the original on 6 August 2014. Retrieved 30 July 2014.
  18. ^ Sundhed Magasinet (PDF). 2007. p. 55. Retrieved 29 July 2014.
  19. ^ Red Barnet Projekt (PDF). Save the Children. March 1990. pp. 2–4. Retrieved 27 October 2014.
  20. ^ "May Olofsson Director of the Family Center Linkedin Profile". Linkedin. Archived from the original on 6 August 2014. Retrieved 30 July 2014.
  21. ^ Underbjerg, M; Kesmodel, US; Landrø, NI; Bakketeig, L; Grove, J; Wimberley, T; Kilburn, TR; Svaerke, C; Thorsen, P; Mortensen, EL (2012). "The effects of low to moderate alcohol consumption and binge drinking in early pregnancy on selective and sustained attention in 5-year-old children" (PDF). BJOG: An International Journal of Obstetrics & Gynaecology. 119 (10): 1211–1221. doi:10.1111/j.1471-0528.2012.03396.x. PMID 22712829. S2CID 31545281. Retrieved 15 July 2014.
  22. ^ Stevens, T. P.; Harrington, E. W.; Blennow, M.; Soll, R. F. (2007-10-17). "Early surfactant administration with brief ventilation vs. selective surfactant and continued mechanical ventilation for preterm infants with or at risk for respiratory distress syndrome". The Cochrane Database of Systematic Reviews. 2008 (4): CD003063. doi:10.1002/14651858.CD003063.pub3. ISSN 1469-493X. PMC 8554819. PMID 17943779.
  23. ^ "Henrik Verder research profile". www.Researchgate.net. Retrieved 15 July 2014.
  24. ^ Verder, H; Robertson, B; Greisen, G; Ebbesen, F; Albertsen, P; Lundstrøm, K; Jacobsen, T (Oct 20, 1994). "Surfactant therapy and nasal continuous positive airway pressure for newborns with respiratory distress syndrome. Danish-Swedish Multicenter Study Group". The New England Journal of Medicine. 331 (16): 1051–5. doi:10.1056/nejm199410203311603. PMID 8090164.
  25. ^ Verder, H; Albertsen, P; Ebbesen, F; Greisen, G; Robertson, B; Bertelsen, A; Agertoft, L; Djernes, B; Nathan, E; Reinholdt, J (Feb 1999). "Nasal continuous positive airway pressure and early surfactant therapy for respiratory distress syndrome in newborns of less than 30 weeks' gestation". Pediatrics. 103 (2): E24. doi:10.1542/peds.103.2.e24. PMID 9925870.
  26. ^ Verder, H; Ebbesen, F; Linderholm, B; Robertson, B; Eschen, C; Arrøe, M; Lange, A; Grytter, C; Bohlin, K; Bertelsen, A; Danish-Swedish Multicentre Study, Group (Jun 2003). "Prediction of respiratory distress syndrome by the microbubble stability test on gastric aspirates in newborns of less than 32 weeks' gestation". Acta Paediatrica. 92 (6): 728–33. doi:10.1080/08035250310002597. PMID 12856986.
  27. ^ Verder, H; Ebbesen, F; Fenger-Grøn, J; Henriksen, TB; Andreasson, B; Bender, L; Bertelsen, A; Björklund, LJ; Dahl, M; Esberg, G; Eschen, C; Høvring, M; Kreft, A; Kroner, J; Lundberg, F; Pedersen, P; Reinholdt, J; Stanchev, H (2013). "Early surfactant guided by lamellar body counts on gastric aspirate in very preterm infants". Neonatology. 104 (2): 116–22. doi:10.1159/000351638. PMID 23942627. S2CID 2699650.
  28. ^ Gluck, L; Kulovich, MV; Borer RC, Jr; Brenner, PH; Anderson, GG; Spellacy, WN (Feb 1, 1971). "Diagnosis of the respiratory distress syndrome by amniocentesis". American Journal of Obstetrics and Gynecology. 109 (3): 440–5. doi:10.1016/0002-9378(71)90342-5. PMID 5107880.
  29. ^ Jessen, Torben E.; Höskuldsson, Agnar T.; Bjerrum, Poul J.; Verder, Henrik; Sørensen, Lars; Bratholm, Palle S.; Christensen, Bo; Jensen, Lene S.; Jensen, Maria A.B. (2014). "Simultaneous determination of glucose, triglycerides, urea, cholesterol, albumin and total protein in human plasma by Fourier transform infrared spectroscopy: Direct clinical biochemistry without reagents". Clinical Biochemistry. 47 (13–14): 1306–12. doi:10.1016/j.clinbiochem.2014.05.064. PMID 24943400.