List of disabled human pseudogenes

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This is a list of human pseudogenes that are known to be disabled genes.

  • WNT3A pseudogene, associated with the growth of a tail[1]
  • NCF1C pseudogene, associated with a type of white blood cell.[2] It makes part of the neutrophil NADPH oxidase enzyme, which makes superoxide anion.[3]
  • GULO pseudogene, associated with the production of Vitamin C
  • IRGM pseudogene, associated with the immune system[4]
  • hHaA pseudogene, associated with fur-like body hair:[5] see hypertrichosis
  • DEFT1P pseudogene, associated with the immune system[6]
  • Urate oxidase pseudogene, associated with the processing of uric acid
  • Photolyase pseudogene, associated with repairing DNA damaged by UV radiation
    • Photolyase is no longer encoded for despite obvious advantages.[7] Instead, this gene is mutated to encode for cryptochromes.


  1. ^
  2. ^ "NCF1C neutrophil cytosolic factor 1C pseudogene [Homo sapiens (human)] - Gene - NCBI". Retrieved 2021-10-14.
  3. ^ "NCF1C Gene - GeneCards | NCF1C Pseudogene". Retrieved 2021-10-14.
  4. ^ Plos genetics on IRGM pseudogene
  5. ^ hHaA pseudogene
  6. ^ Retrocyclin pseudogene reactivation as defense against AIDS
  7. ^ Lucas-Lledó, José Ignacio; Lynch, Michael (2009-05-01). "Evolution of Mutation Rates: Phylogenomic Analysis of the Photolyase/Cryptochrome Family". Molecular Biology and Evolution. 26 (5): 1143–1153. doi:10.1093/molbev/msp029. ISSN 0737-4038. PMC 2668831. PMID 19228922.