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IGH@

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IGH
Identifiers
AliasesIGH, IGD1, IGH.1@, IGH@, IGHD@, IGHDY1, IGHJ, IGHJ@, IGHV, IGHV@, immunoglobulin heavy locus, IgH locus
External IDsOMIM: 146910, 147010, 147070; GeneCards: IGH; OMA:IGH - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed search[1]n/a
Wikidata
View/Edit Human

Immunoglobulin heavy locus, also known as IGH, is a region on human chromosome 14 that contains a gene for the heavy chains of human antibodies (or immunoglobulins).[2]

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Nomenclature

Symbols for variable (V) immunoglobulin genes start with IGHV and include two or three numbers separated by dashes. Examples:

IGHV1-2, IGHV1-3, …, IGHV1-69-2, IGHV2-5, …, IGHV7-4-1

Symbols for diversity (D) immunoglobulin genes start with IGHD and include two numbers separated by dashes. Examples:

IGHD1-1, IGHD1-7, …, IGHD7-27

Symbols for joining (J) immunoglobulin genes:

IGHJ1, IGHJ2, IGHJ3, IGHJ4, IGHJ5, IGHJ6

Symbols for constant region (C) immunoglobulin genes:

Heavy chain alpha (IgA): IGHA1, IGHA2
Heavy chain gamma (IgG): IGHG1, IGHG2, IGHG3, IGHG4
Heavy chain delta (IgD): IGHD
Heavy chain epsilon (IgE): IGHE
Heavy chain mu (IgM): IGHM [3]

See also

References

  1. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. ^ "Entrez Gene: IGH immunoglobulin heavy locus".
  3. ^ "Gene Family: Immunoglobulin heavy locus at 14q32.33 (IGH)". HGNC: HUGO Gene Nomenclature Committee.

Further reading

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