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IMPDH/GMPR family

From Wikipedia, the free encyclopedia
IMP dehydrogenase / GMP reductase domain
binary complex of human type-i inosine monophosphate dehydrogenase with 6-cl-imp
Identifiers
SymbolIMPDH
PfamPF00478
Pfam clanCL0036
InterProIPR001093
PROSITEPDOC00391
SCOP21ak5 / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

In molecular biology, the IMPDH/GMPR family of enzymes includes IMP dehydrogenase and GMP reductase. These enzymes are involved in purine metabolism. These enzymes adopt a TIM barrel structure.[1][2]

References

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  1. ^ Whitby FG, Luecke H, Kuhn P, Somoza JR, Huete-Perez JA, Phillips JD, et al. (1997). "Crystal structure of Tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex". Biochemistry. 36 (35): 10666–74. doi:10.1021/bi9708850. PMID 9271497.
  2. ^ Zhang R, Evans G, Rotella FJ, Westbrook EM, Beno D, Huberman E, et al. (1999). "Characteristics and crystal structure of bacterial inosine-5'-monophosphate dehydrogenase". Biochemistry. 38 (15): 4691–700. doi:10.1021/bi982858v. PMID 10200156.
This article incorporates text from the public domain Pfam and InterPro: IPR001093