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3D model (JSmol)
CompTox Dashboard (EPA)
|Molar mass||215.293 g·mol−1|
|Density||0.998 g/cm3 (at 20 °C)|
|70 g/L (at 20 °C)|
|Solubility in Acetone, ethyl acetate, dichloromethane, n-heptane, methanol, p-xylene||>250 g/L (at RT)|
|log P||1.7 (at 23 °C)|
|GHS Signal word||Warning|
|P280, P305+351+338, P337+313|
|Flash point||159 °C (318 °F; 432 K)|
|Lethal dose or concentration (LD, LC):|
LD50 (median dose)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
Ethyl butylacetylaminopropionate (trade name IR3535) is an insect repellent. As ethyl butylacetylaminopropionate is solely a repellent, it has no killing action and does not give rise to selection pressure or development of resistance. It is a colorless and almost odorless oil and is intended to be applied to the skin of humans and animals. It has a broad efficacy against various insects like mosquitoes, ticks, lice, and other bugs. Ethyl butylacetylaminopropionate is safe for use on infants, pregnant and breastfeeding women. It is biodegradable and completely degraded in the environment within a very short time.
Recent evidence with Anopheles gambiae mosquitoes suggests IR3535 does not activate olfactory receptors neurons, but instead functions to reduce the volatility of the odorants to which it is mixed. By reducing odor volatility, IR3535 functions to "mask" the ability of volatile odorants on the skin to activate olfactory neurons and attract mosquitoes.
- Ethyl butylacetylaminopropionate Product-type 19 (insect repellent)
- 3-(N-Butyl-N-acetyl)-aminopropionic acid, ethyl ester (113509) Technical Document
- 3-(N-Butyl-N-acetyl)-aminopropionic acid, ethyl ester (IR3535) (113509) Fact Sheet
- Afify, Ali; Betz, Joshua F.; Riabinina, Olena; Lahondère, Chloé; Potter, Christopher J. (2019). "Commonly Used Insect Repellents Hide Human Odors from Anopheles Mosquitoes". Current Biology. 29 (21): 3669–3680.e5. doi:10.1016/j.cub.2019.09.007. PMC 6832857. PMID 31630950.
- EPA: Similarity to beta-alanine
- Barnard, Donald R.; Bernier, Ulrich R.; Posey, Kenneth H.; Xue, Rui-De (2002). "Repellency of IR3535, KBR3023,para-menthane-3,8-diol, and Deet to Black Salt Marsh Mosquitoes (Diptera: Culicidae) in the Everglades National Park" (PDF). Journal of Medical Entomology. 39 (6): 895–899. doi:10.1603/0022-2585-39.6.895. PMID 12495189. Archived from the original (PDF) on 2011-07-21.
- Tick Bite Prevention & the Use of Insect Repellents