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An interolog is a conserved interaction between a pair of proteins which have interacting homologs in another organism. The term was introduced in a 2000 paper by Walhout et al.[1][2]



Suppose that A and B are two different interacting human proteins, and A' and B' are two different interacting dog proteins. Then the interaction between A and B is an interolog of the interaction between A' and B' if the following conditions all hold:

  • A is a homolog of A'. (Protein homologs have similar amino acid sequences and derive from a common ancestral sequence).
  • B is a homolog of B'.
  • A and B interact.
  • A' and B' interact.

Thus, interologs are homologous pairs of protein interactions across different organisms.

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  1. ^ Walhout, A. J.; Sordella, R.; Lu, X.; Hartley, J. L.; Temple, G. F.; Brasch, M. A.; Thierry-Mieg, N.; Vidal, M. (2000). "Protein Interaction Mapping in C. Elegans Using Proteins Involved in Vulval Development". Science 287 (5450): 116–122. doi:10.1126/science.287.5450.116. PMID 10615043. 
  2. ^

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