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Interstate 480 may refer to:
- Interstate 480 (Iowa–Nebraska), a loop through Omaha, Nebraska into Council Bluffs, Iowa
- Interstate 480 (Ohio), a loop through Cleveland, Ohio
- Interstate 480 (California), the former Embarcadero Freeway in San Francisco, California
- Interstate 476, designated as Interstate 480 back when I-76 was I-80S
|This disambiguation page lists articles about roads and streets with the same name.
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